8-ethyl-5,7-dimethoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone

Base Information

• Chemical Name: 8-ethyl-5,7-dimethoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone
• CAS No.: 1159283-05-2
• Molecular Formula: C₂₅H₃₂N₄O₆S
• Molecular Weight: 516.618

Synonyms:8-ethyl-5,7-dimethoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone

Chemical Property of 8-ethyl-5,7-dimethoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone

Chemical Property:

Purity/Quality:

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Technology Process of 8-ethyl-5,7-dimethoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone

There total 1 articles about 8-ethyl-5,7-dimethoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

8-bromo-5,7-dimethoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone (1159282-78-6) + ethylzinc chloride (2633-75-2) → 8-ethyl-5,7-dimethoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone (1159283-05-2)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; at 40 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.03.125

Reference yield: 86.0%

8-ethyl-5,7-dimethoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone (1159283-05-2) → 8-ethyl-5-hydroxy-7-methoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone (1159283-14-3)

Guidance literature:

With boron tribromide; In dichloromethane; at -10 ℃;

DOI:10.1016/j.bmcl.2009.03.125

upstream raw materials:

8-bromo-5,7-dimethoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone

ethylzinc chloride

Downstream raw materials:

8-ethyl-5-hydroxy-7-methoxy-2-[5-[(4-methyl-1-piperazinyl)sulfonyl]-2-ethoxybenzoyl]quinazolinone

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