2-[4-hydroxy-3-(methoxycarbonyl)phenyl]-2-methyl-1,3-dioxolane

Base Information

• Chemical Name: 2-[4-hydroxy-3-(methoxycarbonyl)phenyl]-2-methyl-1,3-dioxolane
• CAS No.: 467429-12-5
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.24
• Mol file: 467429-12-5.mol

Synonyms:2-[4-hydroxy-3-(methoxycarbonyl)phenyl]-2-methyl-1,3-dioxolane

Chemical Property of 2-[4-hydroxy-3-(methoxycarbonyl)phenyl]-2-methyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-hydroxy-3-(methoxycarbonyl)phenyl]-2-methyl-1,3-dioxolane

There total 2 articles about 2-[4-hydroxy-3-(methoxycarbonyl)phenyl]-2-methyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

estere metilico dell'acido 5-acetilsalicilico (16475-90-4) + ethylene glycol (107-21-1) → 2-[4-hydroxy-3-(methoxycarbonyl)phenyl]-2-methyl-1,3-dioxolane (467429-12-5)

Guidance literature:

With Triisopropoxymethan; cerium triflate; In hexane; at 25 ℃; for 2h;

DOI:10.1055/s-0028-1088025

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 2-[4-hydroxy-3-(methoxycarbonyl)phenyl]-2-methyl-1,3-dioxolane (467429-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / AlCl₃ / CH₂Cl₂ / 3 h

2: 91 percent / TsOH / toluene / 16 h / Heating

With aluminium trichloride; toluene-4-sulfonic acid; In dichloromethane; toluene; 1: Friedel-Crafts reaction;

DOI:10.1016/S0040-4020(02)00505-7

Reference yield: 85.0%

Ethyl 4-bromobutyrate (2969-81-5) + 2-[4-hydroxy-3-(methoxycarbonyl)phenyl]-2-methyl-1,3-dioxolane (467429-12-5) → 2-(3-ethoxycarbonyl)propoxy-5-(2-methyl-[1,3]-dioxolan-2-yl)benzoic acid methyl ester (467429-13-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h; Heating;

DOI:10.1016/S0040-4020(02)00505-7

upstream raw materials:

estere metilico dell'acido 5-acetilsalicilico

ethylene glycol

methyl salicylate

Downstream raw materials:

2-(3-ethoxycarbonyl)propoxy-5-(2-methyl-[1,3]-dioxolan-2-yl)benzoic acid methyl ester