5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide

Base Information

• Chemical Name: 5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide
• CAS No.: 1570075-95-4
• Molecular Formula: C₂₆H₂₆F₂N₄O₃S
• Molecular Weight: 512.58

Synonyms:5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide

Chemical Property of 5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide

There total 9 articles about 5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide (1570075-93-2) → 5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide (1570075-95-4) + 5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide (1570075-94-3)

Guidance literature:

With Daicel IB; In methanol; diethylamine; at 40 ℃; Resolution of racemate; Supercritical conditions;

Reference yield:

(E/Z)-3-((dimethylamino)methylene)-6-methyl-2H-pyran-2,4(3H)-dione (33821-61-3) → 5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide (1570075-95-4) + 5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide (1570075-94-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium t-butanolate / ethanol / 18 h / 90 °C

2.1: bromine / acetic acid / 74 h / 20 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 18 h / 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / acetonitrile; water / 18 h / 75 °C

5.1: Daicel IB / methanol; diethylamine / 40 °C / Resolution of racemate; Supercritical conditions

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bromine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In methanol; ethanol; water; acetic acid; diethylamine; N,N-dimethyl-formamide; acetonitrile; 4.1: |Suzuki Coupling;

Reference yield:

1-isopropyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (1541148-98-4) → 5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide (1570075-95-4) + 5-(3-(difluoromethyl)phenyl)-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-(N-cyano-S-(methyl)sulfonimidoyl)benzylamide (1570075-94-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: bromine / acetic acid / 74 h / 20 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 18 h / 20 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / acetonitrile; water / 18 h / 75 °C

4.1: Daicel IB / methanol; diethylamine / 40 °C / Resolution of racemate; Supercritical conditions

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bromine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; water; acetic acid; diethylamine; N,N-dimethyl-formamide; acetonitrile; 3.1: |Suzuki Coupling;

upstream raw materials:

(E/Z)-3-((dimethylamino)methylene)-6-methyl-2H-pyran-2,4(3H)-dione

1-isopropyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid

5-bromo-1-isopropyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid

[[4-(aminomethyl)phenyl]-methyl-oxo-λ⁶-sulfanylidene]cyanamide

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