2-{3-[(N-{3-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoic acid

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Chemical Name:2-{3-[(N-{3-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoic acid
CAS No.:1310698-71-5
Molecular Formula:C₃₃H₄₄N₆O₅
Molecular Weight:604.75
Hs Code.:

Synonyms:2-{3-[(N-{3-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoic acid

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Chemical Property of 2-{3-[(N-{3-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoic acid

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Technology Process of 2-{3-[(N-{3-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoic acid

There total 12 articles about 2-{3-[(N-{3-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1310698-67-9
Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate

: 1310698-71-5
2-{3-[(N-{3-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoic acid

Guidance literature:: Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate; With water; sodium hydroxide; In ethanol; at 50 ℃; for 0.5h;

With hydrogenchloride; In ethanol; water; at 0 ℃;

Reference yield:

: 50332-66-6
3-nitro-quinolin-4-ol

: 1310698-71-5
2-{3-[(N-{3-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2.5 h / Reflux

2.1: triethylamine / dichloromethane / 0 °C

3.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 5 - 23 °C

4.1: hydrogenchloride; benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 - 20 °C

6.1: ammonium hydroxide; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C

7.1: hydrogenchloride / water; methanol / 1 h / 50 °C

8.1: sodium cyanoborohydride; acetic acid / methanol / 26 h / 20 °C

9.1: chloroform / 0.33 h / 0 °C

10.1: acetonitrile / 20 h

11.1: sodium hydroxide; water / ethanol / 0.5 h / 50 °C

11.2: 0 °C

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; water; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; triethylamine; N,N-dimethyl-formamide; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; nickel(II) chloride hexahydrate; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; chloroform; water; acetonitrile;

Reference yield:

: 39061-97-7
4-chloro-3-nitroquinoline

: 1310698-71-5
2-{3-[(N-{3-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / dichloromethane / 0 °C

2.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 5 - 23 °C

3.1: hydrogenchloride; benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 - 20 °C

5.1: ammonium hydroxide; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C

6.1: hydrogenchloride / water; methanol / 1 h / 50 °C

7.1: sodium cyanoborohydride; acetic acid / methanol / 26 h / 20 °C

8.1: chloroform / 0.33 h / 0 °C

9.1: acetonitrile / 20 h

10.1: sodium hydroxide; water / ethanol / 0.5 h / 50 °C

10.2: 0 °C

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; water; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; triethylamine; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; nickel(II) chloride hexahydrate; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; chloroform; water; acetonitrile;