Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate

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Chemical Name:Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate
CAS No.:1310698-67-9
Molecular Formula:C₃₅H₄₈N₆O₅
Molecular Weight:632.803
Hs Code.:

Synonyms:Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate

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Chemical Property of Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate

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Technology Process of Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate

There total 11 articles about Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1310698-69-1
Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}-2-methylpropanoate

: 109-89-7
diethylamine

: 1310698-67-9
Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate

Guidance literature:: In acetonitrile; for 20h;

Reference yield:

: 611-36-9
quinolin-4-ol

: 1310698-67-9
Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 11 steps

1: nitric acid / propionic acid / 3.67 h / Reflux

2: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2.5 h / Reflux

3: triethylamine / dichloromethane / 0 °C

4: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 5 - 23 °C

5: hydrogenchloride; benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 - 20 °C

7: ammonium hydroxide; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C

8: hydrogenchloride / water; methanol / 1 h / 50 °C

9: sodium cyanoborohydride; acetic acid / methanol / 26 h / 20 °C

10: chloroform / 0.33 h / 0 °C

11: acetonitrile / 20 h

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; nitric acid; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; triethylamine; N,N-dimethyl-formamide; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; nickel(II) chloride hexahydrate; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; water; propionic acid; acetonitrile;

Reference yield:

: 50332-66-6
3-nitro-quinolin-4-ol

: 1310698-67-9
Ethyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-{diethylamino}acetamido)methyl]phenoxy}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 10 steps

1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2.5 h / Reflux

2: triethylamine / dichloromethane / 0 °C

3: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 5 - 23 °C

4: hydrogenchloride; benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 - 20 °C

6: ammonium hydroxide; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C

7: hydrogenchloride / water; methanol / 1 h / 50 °C

8: sodium cyanoborohydride; acetic acid / methanol / 26 h / 20 °C

9: chloroform / 0.33 h / 0 °C

10: acetonitrile / 20 h

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; triethylamine; N,N-dimethyl-formamide; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; nickel(II) chloride hexahydrate; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; water; acetonitrile;