Trifluoro-methanesulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-6-formyl-phenyl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-6-formyl-phenyl ester
• CAS No.: 197015-40-0
• Molecular Formula: C₁₄H₁₉F₃O₅SSi
• Molecular Weight: 384.449
• Mol file: 197015-40-0.mol

Synonyms:Trifluoro-methanesulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-6-formyl-phenyl ester

Chemical Property of Trifluoro-methanesulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-6-formyl-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trifluoro-methanesulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-6-formyl-phenyl ester

There total 1 articles about Trifluoro-methanesulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-6-formyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3-((tert-butyldimethylsilyl)oxy)-2-hydroxybenzaldehyde → Trifluoro-methanesulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-6-formyl-phenyl ester (197015-40-0)

Guidance literature:

With dmap; In pyridine; Ambient temperature;

DOI:10.1021/jo971377z

Reference yield: 50.0%

tri-n-butyl(vinyl)tin (7486-35-3) + Trifluoro-methanesulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-6-formyl-phenyl ester (197015-40-0) → 3-(tert-Butyl-dimethyl-silanyloxy)-2-vinyl-benzaldehyde (197015-41-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo971377z

Reference yield:

Trifluoro-methanesulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-6-formyl-phenyl ester (197015-40-0) → tert-Butyl-(3-{2-[2-chloro-1-methyl-eth-(E)-ylidene]-cyclobutyl}-2-vinyl-phenoxy)-dimethyl-silane

Guidance literature:

Multi-step reaction with 5 steps

1: 50 percent / LiCl, Pd(PPh₃)4 / tetrahydrofuran / Ambient temperature

2: 84 percent / NaH / tetrahydrofuran

3: 1.) m-chloroperbenzoic acid, 2.) HBF₄ / 1.) CH₂Cl₂, 2.) CH₂Cl₂, room temp.

4: 74 percent / CeCl₃ / tetrahydrofuran

5: SOCl₂, pyridine / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; tetrafluoroboric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; cerium(III) chloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; lithium chloride; In tetrahydrofuran;

DOI:10.1021/jo971377z

upstream raw materials:

trifluoromethylsulfonic anhydride

Downstream raw materials:

3-(tert-Butyl-dimethyl-silanyloxy)-2-vinyl-benzaldehyde

tert-Butyl-(3-cyclopropylidenemethyl-2-vinyl-phenoxy)-dimethyl-silane

2-[3-(tert-Butyl-dimethyl-silanyloxy)-2-vinyl-phenyl]-cyclobutanone

tert-Butyl-dimethyl-(3-{2-[1-methyl-2-phenylsulfanyl-eth-(E)-ylidene]-cyclobutyl}-2-vinyl-phenoxy)-silane