tert-Butyl 4-({5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoate

Base Information

Chemical Name:tert-Butyl 4-({5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoate
CAS No.:1355066-38-4
Molecular Formula:C₂₁H₂₀ClF₄NO₄
Molecular Weight:461.841
Hs Code.:

Synonyms:tert-Butyl 4-({5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoate

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Chemical Property of tert-Butyl 4-({5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoate

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Technology Process of tert-Butyl 4-({5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoate

There total 6 articles about tert-Butyl 4-({5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1355066-37-3
5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-ol

: 182875-05-4
tert-butyl 2,4,5-trifluorobenzoate

: 1355066-38-4
tert-Butyl 4-({5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 446-17-3
2,4,5-trifluorobenzoic acid

: 1355066-38-4
tert-Butyl 4-({5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / tert-butyl alcohol / 16 h / 30 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C / Inert atmosphere

With potassium carbonate; dmap; In dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 107496-54-8
3,3-difluorocyclobutanecarboxylic acid

: 1355066-38-4
tert-Butyl 4-({5-chloro-6-[(3,3-difluorocyclobutyl)methoxy]pyridin-3-yl}oxy)-2,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 16 h / Reflux

3.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / 1,4-dioxane / 60 h / 20 °C / Inert atmosphere

4.1: dihydrogen peroxide; methanol / 16 h / 20 °C / Inert atmosphere

5.1: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C / Inert atmosphere

With methanol; dimethylsulfide borane complex; dihydrogen peroxide; sodium hydride; potassium carbonate; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; mineral oil;