2-[3-(3-Benzoyl-1-methyl-thioureido)-phenyl]-propionic acid ethyl ester

Base Information

Chemical Name:2-[3-(3-Benzoyl-1-methyl-thioureido)-phenyl]-propionic acid ethyl ester
CAS No.:88975-73-9
Molecular Formula:C₂₀H₂₂N₂O₃S
Molecular Weight:370.472
Hs Code.:

Synonyms:2-[3-(3-Benzoyl-1-methyl-thioureido)-phenyl]-propionic acid ethyl ester

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Chemical Property of 2-[3-(3-Benzoyl-1-methyl-thioureido)-phenyl]-propionic acid ethyl ester

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Technology Process of 2-[3-(3-Benzoyl-1-methyl-thioureido)-phenyl]-propionic acid ethyl ester

There total 5 articles about 2-[3-(3-Benzoyl-1-methyl-thioureido)-phenyl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 98-88-4
benzoyl chloride

: 88975-24-0
2-(3-Methylamino-phenyl)-propionic acid ethyl ester

: 88975-73-9
2-[3-(3-Benzoyl-1-methyl-thioureido)-phenyl]-propionic acid ethyl ester

Guidance literature:: With ammonium thiocyanate; In acetone; for 1h; Ambient temperature;
DOI:10.1248/cpb.31.3424

Reference yield:

: 88975-15-9
2-(4-Chloro-3-nitro-phenyl)-propionic acid ethyl ester

: 88975-73-9
2-[3-(3-Benzoyl-1-methyl-thioureido)-phenyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / H₂/potassium acetate / 5percent Pd-C / ethanol / Ambient temperature

2: 100 percent / CH₂Cl₂ / 1 h / Ambient temperature

3: K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

4: metallic sodium/abs. ethanol / 0.5 h / Ambient temperature

5: 94 percent / NH₄SCN / acetone / 1 h / Ambient temperature

With ethanol; hydrogen; ammonium thiocyanate; potassium acetate; sodium; potassium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.31.3424

Reference yield:

: 68285-88-1
ethyl 2-(3-aminophenyl)propionate

: 88975-73-9
2-[3-(3-Benzoyl-1-methyl-thioureido)-phenyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / CH₂Cl₂ / 1 h / Ambient temperature

2: K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

3: metallic sodium/abs. ethanol / 0.5 h / Ambient temperature

4: 94 percent / NH₄SCN / acetone / 1 h / Ambient temperature

With ethanol; ammonium thiocyanate; sodium; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.31.3424