5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole

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Chemical Name:5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole
CAS No.:1430210-67-5
Molecular Formula:C₃₂H₃₃FN₄O₃S
Molecular Weight:572.703
Hs Code.:

Synonyms:5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole

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Chemical Property of 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole

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Technology Process of 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole

There total 10 articles about 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 2-((2-bromoethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 81376-54-7
1-(4-hydroxyphenyl)-2-methylimidazole

: 1430210-67-5
5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 70 ℃; for 5h; Temperature; Inert atmosphere;
DOI:10.1021/acsmedchemlett.5b00323

Reference yield:

: 4461-99-8
3-(3,4-dimethoxyphenyl)-3-methylbutan-2-one

: 1430210-67-5
5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetra-N-butylammonium tribromide / dichloromethane; methanol / 7 h / 0 - 20 °C

2.1: hexamethylenetetramine / dichloromethane / 48 h / 20 °C

2.2: 3 h / 0 °C / Reflux

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: acetic acid / 3 h / 118 °C

5.1: acetone / 2 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 5 h / 70 °C / Inert atmosphere

With hexamethylenetetramine; tetra-N-butylammonium tribromide; potassium carbonate; acetic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; 2.1: |Delepine Amine Synthesis / 2.2: |Delepine Amine Synthesis;
DOI:10.1021/acsmedchemlett.5b00323

Reference yield:

: 1430211-87-2
1-bromo-3-(3,4-dimethoxyphenyl)-3-methylbutan-2-one

: 1430210-67-5
5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: hexamethylenetetramine / dichloromethane / 48 h / 20 °C

1.2: 3 h / 0 °C / Reflux

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: acetic acid / 3 h / 118 °C

4.1: acetone / 2 h / 20 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 5 h / 70 °C / Inert atmosphere

With hexamethylenetetramine; potassium carbonate; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; 1.1: |Delepine Amine Synthesis / 1.2: |Delepine Amine Synthesis;
DOI:10.1021/acsmedchemlett.5b00323