5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Base Information

Chemical Name:5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol
CAS No.:1239963-74-6
Molecular Formula:C₂₀H₂₁FN₂O₂S
Molecular Weight:372.463
Hs Code.:

Synonyms:5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

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Chemical Property of 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

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Technology Process of 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

There total 16 articles about 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1-(3-(3,4-dimethoxyphenyl)-3-methyl-2-oxobutyl)-3-(4-fluorophenyl)thiourea

: 1239963-74-6
5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Guidance literature:: With acetic acid; for 3h; Reflux; Inert atmosphere;
DOI:10.1021/acs.oprd.0c00234

Reference yield:

: 1-(3-(3,4-dimethoxyphenyl)-3-methyl-2-oxobutyl)-3-(4-fluorophenyl)thiourea

: 1239963-74-6
5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2(3H)-thione

Guidance literature:: With acetic acid; for 8h; Reflux;

Reference yield:

: 717105-57-2
2-(3,4-dimethoxyphenyl)-2-methylpropanal

: 1239963-74-6
5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2(3H)-thione

Guidance literature:: Multi-step reaction with 5 steps

1: potassium fluoride / ethanol / 20 °C

2: pyridinium chlorochromate / dichloromethane / 72 h / Molecular sieve

3: hydrogenchloride; hydrogen; acetic acid / palladium 10% on activated carbon / 48 h / 3102.97 Torr

4: triethylamine / benzene / 8 h / Reflux

5: acetic acid / 8 h / Reflux

With hydrogenchloride; potassium fluoride; hydrogen; acetic acid; triethylamine; pyridinium chlorochromate; palladium 10% on activated carbon; In ethanol; dichloromethane; benzene;