10.1016/j.bmcl.2009.12.034
The study focuses on the asymmetric syntheses of daedalin A and quercinol, which are compounds derived from mushroom mycelia cultures with potential tyrosinase inhibitory activity, important for preventing hyperpigmentation in cosmetics. The chemicals used in the study include 4-methoxyphenol, vinyloxirane, Pd(PPh3)4 (a palladium catalyst), acetic anhydride, ethyl acetate, and various other reagents for reactions such as acetylation, Claisen rearrangement, Sharpless asymmetric epoxidation, reduction, oxidation, and deprotection. These chemicals served the purpose of synthesizing daedalin A and quercinol through a series of chemical reactions, with the aim of studying their inhibitory effects on tyrosinase, a key enzyme in melanin biosynthesis. The study found that daedalin A had stronger tyrosinase inhibitory activity than quercinol at high concentrations, suggesting different mechanisms of action due to their opposite stereochemistry at the C-2 position.
10.1080/07391102.2020.1805364
The study focuses on the synthesis and evaluation of 3-hydroxyflavone derivatives as inhibitors of mushroom tyrosinase, an enzyme involved in melanin production. A series of 3-hydroxyflavone scaffolds were synthesized using the Algar-Flynn-Oyamada reaction, and these compounds were screened for their in vitro inhibitory activity against tyrosinase. The chemicals used in the study included o-hydroxyacetophenone, various substituted benzaldehydes, sodium hydroxide, methanol, and hydrogen peroxide. These chemicals served the purpose of reacting together to form the desired 3-hydroxyflavone derivatives, which were then tested for their antimicrobial potential and their ability to inhibit tyrosinase, providing insights into their potential use as therapeutic agents for pigmentation-related disorders and as antimicrobial agents. The study also involved the use of spectroscopic techniques and mass spectrometry for compound characterization, as well as molecular modeling to explore binding interactions with the tyrosinase enzyme.
