Technology Process of ethyl 2-(3,5-bisbenzyloxyphenyl)-2-methoxycarbonylacetate
There total 8 articles about ethyl 2-(3,5-bisbenzyloxyphenyl)-2-methoxycarbonylacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 97 percent / Et3N / CH2Cl2 / 1.75 h / 0 °C
2: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C
3: 97 percent / KOH / ethanol / 18 h / Heating
4: 96 percent / HCl / 16.5 h
5: 92 percent / K2CO3 / acetonitrile / 21 h / 23 °C
6: 1.) lithium di-isopropylamide / 1.) THF, -76 deg C, 0.5 h, 2.) 3 h
With
hydrogenchloride; potassium hydroxide; potassium carbonate; triethylamine; lithium diisopropyl amide;
In
ethanol; dichloromethane; 2-methoxy-ethanol; acetonitrile;
DOI:10.1039/P19810002825
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 97 percent / Red-al / toluene / 4 h / Heating
2: 97 percent / Et3N / CH2Cl2 / 1.75 h / 0 °C
3: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C
4: 97 percent / KOH / ethanol / 18 h / Heating
5: 96 percent / HCl / 16.5 h
6: 92 percent / K2CO3 / acetonitrile / 21 h / 23 °C
7: 1.) lithium di-isopropylamide / 1.) THF, -76 deg C, 0.5 h, 2.) 3 h
With
hydrogenchloride; potassium hydroxide; potassium carbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide;
In
ethanol; dichloromethane; 2-methoxy-ethanol; toluene; acetonitrile;
DOI:10.1039/P19810002825
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 100 percent / HCl / 5 h / Heating
2: 95 percent / K2CO3 / acetone / 4.5 h / Heating
3: 97 percent / Red-al / toluene / 4 h / Heating
4: 97 percent / Et3N / CH2Cl2 / 1.75 h / 0 °C
5: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C
6: 97 percent / KOH / ethanol / 18 h / Heating
7: 96 percent / HCl / 16.5 h
8: 92 percent / K2CO3 / acetonitrile / 21 h / 23 °C
9: 1.) lithium di-isopropylamide / 1.) THF, -76 deg C, 0.5 h, 2.) 3 h
With
hydrogenchloride; potassium hydroxide; potassium carbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide;
In
ethanol; dichloromethane; 2-methoxy-ethanol; acetone; toluene; acetonitrile;
DOI:10.1039/P19810002825