Technology Process of ethyl methyl 3,5-bisbenzyloxyphenyl(prop-2-ynyl)malonate
There total 10 articles about ethyl methyl 3,5-bisbenzyloxyphenyl(prop-2-ynyl)malonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetra(n-butyl)ammonium hydroxide;
In
sodium hydroxide; dichloromethane;
for 25h;
DOI:10.1039/P19810002825
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 97 percent / Red-al / toluene / 4 h / Heating
2: 97 percent / Et3N / CH2Cl2 / 1.75 h / 0 °C
3: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C
4: 97 percent / KOH / ethanol / 18 h / Heating
5: 96 percent / HCl / 16.5 h
6: 92 percent / K2CO3 / acetonitrile / 21 h / 23 °C
7: 1.) lithium di-isopropylamide / 1.) THF, -76 deg C, 0.5 h, 2.) 3 h
8: 100 percent / tetra-n-butylammonium hydroxide / CH2Cl2; aq. NaOH / 25 h
With
hydrogenchloride; potassium hydroxide; tetra(n-butyl)ammonium hydroxide; potassium carbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide;
In
sodium hydroxide; ethanol; dichloromethane; 2-methoxy-ethanol; toluene; acetonitrile;
DOI:10.1039/P19810002825
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 97 percent / Et3N / CH2Cl2 / 1.75 h / 0 °C
2: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C
3: 97 percent / KOH / ethanol / 18 h / Heating
4: 96 percent / HCl / 16.5 h
5: 92 percent / K2CO3 / acetonitrile / 21 h / 23 °C
6: 1.) lithium di-isopropylamide / 1.) THF, -76 deg C, 0.5 h, 2.) 3 h
7: 100 percent / tetra-n-butylammonium hydroxide / CH2Cl2; aq. NaOH / 25 h
With
hydrogenchloride; potassium hydroxide; tetra(n-butyl)ammonium hydroxide; potassium carbonate; triethylamine; lithium diisopropyl amide;
In
sodium hydroxide; ethanol; dichloromethane; 2-methoxy-ethanol; acetonitrile;
DOI:10.1039/P19810002825
