Heparin sodium

Base Information

• Chemical Name: Heparin sodium
• CAS No.: 9041-08-1
• Deprecated CAS: 104521-37-1,9075-96-1,91449-79-5,11078-24-3,11129-39-8,37324-73-5,1108625-99-5,1108626-06-7
• Molecular Formula: Unspecified
• Hs Code.: 30019010
• DSSTox Substance ID: DTXSID80872762
• Wikidata: Q105969973
• NCI Thesaurus Code: C1452,C1453,C173512,C539,C78447,C87297,C142899,C2578
• RXCUI: 67108,67109,235473,2368733
• Mol file: 9041-08-1.mol

Synonyms:Alfa87-120;Alfa 87-163;Alfa 87-198;Alfa 87-81;Alfa 88-247;Ardeparin sodium;Badyket;Clivarin 1750;Fragmin;Fragmin IV;H 2149;Hed-Heparin;Hepaflush;Hepagumin;Hepalean;Heparin Fragment Kabi 2165;Heparin sodium;HeparineChoay;Heprinar;Hepsal;Ivor;Kabi 2165;LHN 1;Lioton1000;Lipo-Hepin;Lipo-Hepinette;Longheparin;Minihep;Monoparin;Normiflo;RO 11;Thromboliquine;Unihep;Viatromb;WY 90493RD;Zibor;

Chemical Property of Heparin sodium

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL, clear, faintly yellow
• Water Solubility.: Soluble in water, dimethyl sulfoxide and ethanol.
• XLogP3: -10.8
• Hydrogen Bond Donor Count: 15
• Hydrogen Bond Acceptor Count: 38
• Rotatable Bond Count: 21
• Exact Mass: 1134.0069961
• Heavy Atom Count: 70
• Complexity: 2410

Purity/Quality:

99.9% ^*data from raw suppliers

Heparin sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38-42/43:
• Hazard Codes: R36/37/38-42/43:
• Statements: 36/37/38-42/43
• Safety Statements: 22-24-26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)NC1C(C(C(OC1O)COS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)OC4C(C(C(C(O4)C(=O)O)O)O)OS(=O)(=O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O
• Recent ClinicalTrials: Evaluation of Chemical Venous Thromboembolism Prophylaxis in Trauma
• Recent EU Clinical Trials: Comparison of Anticoagulation Strategies using Unfractionated heparin,
• Recent NIPH Clinical Trials: A Study of JNJ-70033093 (BMS-986177) Versus Subcutaneous Enoxaparin in Participants Undergoing Elective Total Knee Replacement Surgery
• Drug Interactions: Heparin should not be combined with double coumarin, nonsteroidal anti-inflammatory drug, dipyridamole, dextran, corticosteroids, uric acid, and urokinase which can exacerbate bleeding; Combination with methimazole and propylthiouracil has a synergistic effect. This product has incompatibility with cefotaxime pyridine, cephalothin, daunorubicin, azithromycin, erythromycin, hyaluronidase, aminoglycoside antibiotics, polymyxin B, vancomycin, hydrocortisone, chlorpromazine, and promethazine.
• Uses: 1. Biochemical studies; used for preventing the conversion of prothrombin into thrombin; has blood anti-thrombosis effect. 2. For the delay and prevention of blood clotting. 3. Heparin sodium salt is a mucopolysaccharides biochemical medicine extracted from porcine small intestinal mucosa with strong anticoagulant activity. Mclcan found it from the liver tissue of dog in the study of the clotting mechanism. Brinkous et al proved that heparin having anticoagulant activity. After the first application of heparin as an anticoagulant in clinical filed, it has drawn worldwide attention. With a strong anticoagulant effect, heparin is the primary choice for prevention and treatment of deep vein thrombosis and other thrombotic diseases. Although has more than 60 years of clinical history, so far people haven’t develop a complete substitute of it and thereby it is still the most important anticoagulant and antithrombotic drug of biochemistry. It has a wide application in pharmacy where it is used for the treatment of acute myocardial infarction and toxin-hepatitis. Combination with ribonucleic acid can further increase the its efficacy on treating hepatitis B. Combined with chemotherapy, it helps prevent the formation of blood clots, lower blood fat and enhance immunity. Low molecular weight heparin has anticoagulant Factor Xa activity. Pharmacodynamic studies have shown that low molecular weight heparin has inhibitory effect on both in vivo and in vitro thrombosis and arterial-venous thrombosis but has less impact on blood coagulation and fibrinolysis system. There is a low possibility of bleeding when it produces antithrombotic effect. Ordinary heparin is a mixture containing a variety of amino dextran glycosides. It can delay or prevent blood coagulation both in vitro and in vivo. Its anticoagulant mechanism is very complicated, and has a role in all processes of blood coagulation including inhibiting the conversion of prothrombin into thrombin; inhibition of thrombin activity; prevent conversion of fibrinogen into fibrin; prevent platelet aggregation and destruction. Heparin can also reduce cholesterol, lower LDL and VLDL, increase HDL, change blood viscosity, protect vascular endothelial cells, prevent atherosclerosis, boost blood flow, and improve coronary circulation. for coagulation proteins, nucleic acids Heparin sodium salt is used as a blood anti-coagulant. It is also used as an effective inhibitor of mesenchymal cell proliferation. Further, it binds to antithrombin III, which inhibits coagulation proteases. It is used as a major component of serum free media for preventing cell aggregation. It is also used as an anti-cancer agent in in vitro cancer research.
• Production method: Extract the intestinal mucosa of pigs, sheep, and cattle, refine to obtain it.
• Description: Reviparin sodium, a second-generation low molecular weight heparin produced from porcine mucosal heparin, has been introduced for the prevention of deep vein thrombosis and pulmonary embolism following surgery. It has sustained activity and increased bioavailability over unfractioned heparin. More noticeably, reviparin shows a pronounced inhibitory effect, both in vitro and in vivo , on smooth muscle cell proliferation which plays a predominant role in restenosis following angioplasty. Indeed, a lower incidence of restenosis without major bleeding complications has been reported for reviparin treated patients who successfully underwent percutaneous transluminal coronary angioplasty.
• Therapeutic Function: Anticoagulant, Antithrombotic