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9041-08-1

Basic Information
CAS No.: 9041-08-1
Name: Heparin sodium
Molecular Structure:
Molecular Structure of 9041-08-1 (Heparin sodium)
Formula: Unspecified
Synonyms: Alfa87-120;Alfa 87-163;Alfa 87-198;Alfa 87-81;Alfa 88-247;Ardeparin sodium;Badyket;Clivarin 1750;Fragmin;Fragmin IV;H 2149;Hed-Heparin;Hepaflush;Hepagumin;Hepalean;Heparin Fragment Kabi 2165;Heparin sodium;HeparineChoay;Heprinar;Hepsal;Ivor;Kabi 2165;LHN 1;Lioton1000;Lipo-Hepin;Lipo-Hepinette;Longheparin;Minihep;Monoparin;Normiflo;RO 11;Thromboliquine;Unihep;Viatromb;WY 90493RD;Zibor;
EINECS: 232-681-7
Solubility: Soluble in water
Hazard Symbols: R36/37/38-42/43:;
Risk Codes: 36/37/38-42/43
Safety: 22-24-26-36/37
PSA: 0.00000
LogP: 0.00000
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Chemistry

Synonyms: Ardeparin sodium ; Deligoparin sodium ; Minolteparin sodium ; Nadroparine sodium
Chemical Formula: ca. (C12H16NS2Na3)20
Molecular Weight: ca. 12000 
EINECS: 232-681-7
storage temp.:  2-8°C
solubility:  H2O: 50 mg/mL, clear, faintly yellow
Form of Heparin sodium(CAS NO.9041-08-1): crystalline (fine)
Appearance of Heparin sodium (CAS NO.9041-08-1): white powder
Odor: Odorless.
pH: 6.0-7.5 (1% aqueous solution)
Merck: 14,4653

Toxicity Data With Reference

1.    

scu-wmn TDLo:3400 units/kg/17D-I:SKN

    DICPBB    Drug Intelligence and Clinical Pharmacy. 18 (1984),313.
2.    

scu-man TDLo:7 mg/kg/4D:CNS,SKN,BLD

    JAMAAP    JAMA, Journal of the American Medical Association. 244 (1980),1831.
3.    

ivn-wmn TDLo:700 units/kg/13D-I:BLD

    NEJMAG    New England Journal of Medicine. 303 (1980),788.
4.    

ivn-rat LD50:354 mg/kg

    DEBIDR    Developments in Biochemistry. 12 (1981),535.
5.    

ivn-mus LD50:2800 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 102 (1951),156.
6.    

ivn-dog LD50:1 g/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 102 (1951),156.

 Heparin sodium (CAS NO.9041-08-1) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.
 

Safety Profile

Risk Statements: 36/37/38-42/43 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements: 22-24-26-36/37 
S22:Do not breathe dust. 
S24:Avoid contact with skin. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37:Wear suitable protective clothing and gloves.
WGK Germany: 2
RTECS: MI0850000
F: 3-10
Poison by intravenous route. Human systemic effects: corrosive dermatitis, hallucinations and distorted perceptions, hemorrhage, thrombocytopenia. When heated to decomposition it emits toxic fumes of NOx and Na2O. See also HEPARIN.

Standards and Recommendations

Assay of HEPARIN SODIUM: 98 - 100%

Specification

 Heparin sodium (CAS NO.9041-08-1) should be kept in a tightly closed container, stored in a cool, dry, ventilated area. we should protect against physical damage.It should isolate from incompatible substances. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product. Heparin sodium (CAS NO.9041-08-1) is stable at room temperature in closed containers under normal storage and handling conditions, and incompatible with strong oxidizing agents, strong bases. Heparin sodium (CAS NO.9041-08-1)should avoid the condition like incompatible materials, excess heat, exposure to moist air or water. It is incompatibilities with other materials strong oxidizing agents. Its hazardous decomposition products are carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide, sodium oxide.

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