methyl O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-tyrosinate

Base Information

Chemical Name:methyl O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-tyrosinate
CAS No.:959992-80-4
Molecular Formula:C₂₀H₂₅N₃O₃
Molecular Weight:355.437
Hs Code.:

Synonyms:methyl O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-tyrosinate

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Chemical Property of methyl O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-tyrosinate

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Technology Process of methyl O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-tyrosinate

There total 4 articles about methyl O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 243641-39-6
2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanol

: 959992-80-4
methyl O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-tyrosinate

Guidance literature:: (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester; 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanol; With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In dichloromethane; at -30 - 25 ℃; for 18.17h;

With trifluoroacetic acid; at 17 - 25 ℃; for 2h;

With methanol; ammonia; In dichloromethane; at 0 ℃;

Reference yield:

: C₂₅H₃₃N₃O₅

: 959992-80-4
methyl O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-tyrosinate

Guidance literature:: C₂₅H₃₃N₃O₅; With trifluoroacetic acid; In dichloromethane; at 17 - 25 ℃; for 2h;

With methanol; ammonia; In dichloromethane; at 0 ℃;

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 959992-80-4
methyl O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-tyrosinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / dichloromethane / 18.08 h / -30 - 20 °C

2.1: trifluoroacetic acid / 2 h / 20 °C

2.2: 0 °C

With triphenylphosphine; trifluoroacetic acid; 1,1'-azodicarbonyl-dipiperidine; In dichloromethane;