1,8-Naphthyridine-2-ethanol, 1,5,6,7-tetrahydro-

Base Information

• Chemical Name: 1,8-Naphthyridine-2-ethanol, 1,5,6,7-tetrahydro-
• CAS No.: 243641-39-6
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.234
• Mol file: 243641-39-6.mol

Synonyms:7-(2-hydroxyethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine;2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-ethanol;2-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-ethanol;2-(5, 6,7,8-tetrahydro-1,8-naphthyridin-2-yl) ethanol;5,6,7,8-tetrahydro-1,8-Naphthyridine-2-ethanol;

Chemical Property of 1,8-Naphthyridine-2-ethanol, 1,5,6,7-tetrahydro-

Chemical Property:

• PSA: 45.15000
• LogP: 1.11250

Purity/Quality:

NLT 98% ^*data from raw suppliers

5,6,7,8-tetrahydro-1,8-Naphthyridine-2-ethanol 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,6,7,8-Tetrahydro-1,8-naphthyridine-2-ethanol is used in the preparation of integrin targeting ligands for the treatment and prevention of diseases.

Technology Process of 1,8-Naphthyridine-2-ethanol, 1,5,6,7-tetrahydro-

There total 10 articles about 1,8-Naphthyridine-2-ethanol, 1,5,6,7-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

7-ethoxycarbonylmethyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (243641-38-5) → 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanol (243641-39-6) + tert-butyl 7-(2-hydroxyethyl)-3,4-dihydro-1,8-naphthyridine-1(12H)-carboxylate (445490-78-8)

Guidance literature:

7-ethoxycarbonylmethyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester; With lithium borohydride; In tetrahydrofuran; at 20 ℃;

With water; In tetrahydrofuran; at 20 ℃; for 0.166667h;

Reference yield: 85.0%

ethyl (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)acetate (721920-80-5) → 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanol (243641-39-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 15 - 20 ℃; for 4h;

Reference yield: 66.0%

7-ethoxycarbonylmethyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (243641-38-5) → 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanol (243641-39-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; lithium borohydride; sodium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; ethyl acetate;

upstream raw materials:

tert-butyl 7-(2-hydroxyethyl)-3,4-dihydro-1,8-naphthyridine-1(12H)-carboxylate

ethyl (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)acetate

[1,8]naphthyridin-2-yl-acetic acid ethyl ester

2-Aminonicotinaldehyde

Downstream raw materials:

ethyl (S)-3-phenyl-4-[4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-ethoxy]phenyl]butanoate

3-[2-(4-chloro-phenyl)-thiazol-5-yl]-4-{3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-ethoxy]-isoxazol-5-yl}-butyric acid ethyl ester

(2-Methyl-2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic Acid Trifluoroacetate

ethyl (2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}cyclopropyl)acetate