(E)-(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-(4-methoxyphenyl)acrylate

Base Information

Chemical Name:(E)-(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-(4-methoxyphenyl)acrylate
CAS No.:89013-68-3
Molecular Formula:C₃₀H₃₂O₉
Molecular Weight:536.579
Hs Code.:

Synonyms:(E)-(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-(4-methoxyphenyl)acrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-(4-methoxyphenyl)acrylate

Chemical Property:

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Technology Process of (E)-(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-(4-methoxyphenyl)acrylate

There total 3 articles about (E)-(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-(4-methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.4%

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 3143-37-1
(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-ol

: 89013-68-3
(E)-(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-(4-methoxyphenyl)acrylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b00085

Reference yield:

: 89013-65-0,110548-83-9
(-)-epigallocatechin 3-O-p-coumaroate

: 77-78-1
dimethyl sulfate

: 89013-68-3
(E)-(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-(4-methoxyphenyl)acrylate

Guidance literature:: With potassium carbonate; In acetone; for 1.5h; Heating;

Reference yield:

: 873936-01-7
(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3,4,5-trimethoxybenzoate

: 89013-68-3
(E)-(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-(4-methoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; potassium carbonate / 1,2-dimethoxyethane / 2 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C / Inert atmosphere

With methanol; dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/acs.jmedchem.5b00085