4-(4-(benzylthio)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine

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Chemical Name:4-(4-(benzylthio)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine
CAS No.:1391926-34-3
Molecular Formula:C₂₆H₂₈N₆O₂S
Molecular Weight:488.613
Hs Code.:

Synonyms:4-(4-(benzylthio)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine

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Chemical Property of 4-(4-(benzylthio)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine

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Technology Process of 4-(4-(benzylthio)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine

There total 10 articles about 4-(4-(benzylthio)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1146955-35-2
2-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole

: 1391926-33-2
4-(4-(benzylthio)-6-chloro-1,3,5-triazin-2-yl)morpholine

: 1391926-34-3
4-(4-(benzylthio)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 18h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.5b00322

Reference yield:

: 603-83-8
3-nitro-o-tolylamine

: 1391926-34-3
4-(4-(benzylthio)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium nitrite / water; acetic acid / 2 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / -5 °C

3.2: 0.17 h

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 20 °C

5.1: trifluoroacetic acid / ethyl acetate

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium carbonate; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; trifluoroacetic acid; In methanol; 1,2-dimethoxyethane; ethanol; water; acetic acid; ethyl acetate;

Reference yield:

: 41748-71-4
4-aminoindazole

: 1391926-34-3
4-(4-(benzylthio)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / -5 °C

1.2: 0.17 h

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 20 °C

3.1: trifluoroacetic acid / ethyl acetate

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

With hydrogenchloride; sodium carbonate; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluoroacetic acid; In methanol; 1,2-dimethoxyethane; water; ethyl acetate;