Technology Process of 4-(4-(benzylsulfonyl)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine
There total 10 articles about 4-(4-(benzylsulfonyl)-6-(2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-yl)-1,3,5-triazin-2-yl)morpholine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Oxone;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 25h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium nitrite / water; acetic acid / 2 h / 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere
3.1: hydrogenchloride; sodium nitrite / water / -5 °C
3.2: 0.17 h
4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 20 °C
5.1: trifluoroacetic acid / ethyl acetate
6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere
7.1: Oxone / water; tetrahydrofuran / 25 h / 0 - 20 °C
With
hydrogenchloride; Oxone; hydrogen; sodium carbonate; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; trifluoroacetic acid;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; acetic acid; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; sodium nitrite / water / -5 °C
1.2: 0.17 h
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 20 °C
3.1: trifluoroacetic acid / ethyl acetate
4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere
5.1: Oxone / water; tetrahydrofuran / 25 h / 0 - 20 °C
With
hydrogenchloride; Oxone; sodium carbonate; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); trifluoroacetic acid;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate;