methyl 4-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-methoxypyridin-5-yl)-2,3-difluorobenzoate

Base Information

Chemical Name:methyl 4-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-methoxypyridin-5-yl)-2,3-difluorobenzoate
CAS No.:1621254-34-9
Molecular Formula:C₃₅H₃₂F₈N₂O₅
Molecular Weight:712.637
Hs Code.:

methyl 4-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-methoxypyridin-5-yl)-2,3-difluorobenzoate

Synonyms:methyl 4-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-methoxypyridin-5-yl)-2,3-difluorobenzoate

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Chemical Property of methyl 4-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-methoxypyridin-5-yl)-2,3-difluorobenzoate

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Technology Process of methyl 4-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-methoxypyridin-5-yl)-2,3-difluorobenzoate

There total 7 articles about methyl 4-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-methoxypyridin-5-yl)-2,3-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.8%

: 1621255-73-9
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

: 1621256-23-2
C₁₄H₁₇BF₂O₄

: 1621254-34-9
methyl 4-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-methoxypyridin-5-yl)-2,3-difluorobenzoate

Guidance literature:: With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1621255-70-6
ethyl 2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enecarboxylate

: 1621254-34-9
methyl 4-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-methoxypyridin-5-yl)-2,3-difluorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2: Dess-Martin periodane / dichloromethane / 0.5 h / 0 - 20 °C

3: sodium cyanoborohydride; acetic acid / dichloromethane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

5: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

With lithium aluminium tetrahydride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium cyanoborohydride; sodium carbonate; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 5: |Suzuki Coupling;

Reference yield:

: 1423046-22-3
C₁₇H₂₉BO₄

: 1621254-34-9
methyl 4-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-methoxypyridin-5-yl)-2,3-difluorobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

3: Dess-Martin periodane / dichloromethane / 0.5 h / 0 - 20 °C

4: sodium cyanoborohydride; acetic acid / dichloromethane / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

6: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium cyanoborohydride; sodium carbonate; caesium carbonate; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 1: |Suzuki Coupling / 6: |Suzuki Coupling;