ethyl (2S,3R)-N-tert-butoxycarbonyl-3-(p-trifluoromethylphenyl)pyroglutamate

Base Information

Chemical Name:ethyl (2S,3R)-N-tert-butoxycarbonyl-3-(p-trifluoromethylphenyl)pyroglutamate
CAS No.:528607-20-7
Molecular Formula:C₁₉H₂₂F₃NO₅
Molecular Weight:401.383
Hs Code.:

Synonyms:ethyl (2S,3R)-N-tert-butoxycarbonyl-3-(p-trifluoromethylphenyl)pyroglutamate

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Chemical Property of ethyl (2S,3R)-N-tert-butoxycarbonyl-3-(p-trifluoromethylphenyl)pyroglutamate

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Technology Process of ethyl (2S,3R)-N-tert-butoxycarbonyl-3-(p-trifluoromethylphenyl)pyroglutamate

There total 2 articles about ethyl (2S,3R)-N-tert-butoxycarbonyl-3-(p-trifluoromethylphenyl)pyroglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (2S,3R)-5-Oxo-3-(4-trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester

: 528607-20-7
ethyl (2S,3R)-N-tert-butoxycarbonyl-3-(p-trifluoromethylphenyl)pyroglutamate

Guidance literature:: With dmap; In acetonitrile; at 20 ℃;
DOI:10.1021/jo0495438

Reference yield:

: 291763-97-8
(2S,3R)-3-(p-trifluoromethylphenyl)pyroglutamic acid

: 528607-20-7
ethyl (2S,3R)-N-tert-butoxycarbonyl-3-(p-trifluoromethylphenyl)pyroglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 20 °C

2: DMAP / acetonitrile / 20 °C

With dmap; thionyl chloride; In acetonitrile;
DOI:10.1021/jo0495438