(2S,3R)-3-(4-Trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester

Base Information

Chemical Name:(2S,3R)-3-(4-Trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester
CAS No.:528607-37-6
Molecular Formula:C₁₄H₁₆F₃NO₂
Molecular Weight:287.282
Hs Code.:

Synonyms:(2S,3R)-3-(4-Trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester

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Chemical Property of (2S,3R)-3-(4-Trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester

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Technology Process of (2S,3R)-3-(4-Trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester

There total 4 articles about (2S,3R)-3-(4-Trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3R)-5-Hydroxy-3-(4-trifluoromethyl-phenyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

: 528607-37-6
(2S,3R)-3-(4-Trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at -78 - 20 ℃; for 1h;
DOI:10.1021/jo0495438

Reference yield:

: 291763-97-8
(2S,3R)-3-(p-trifluoromethylphenyl)pyroglutamic acid

: 528607-37-6
(2S,3R)-3-(4-Trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 20 °C

2: DMAP / acetonitrile / 20 °C

3: lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C

4: triethylsilane; boron trifluoride etherate / CH₂Cl₂ / 1 h / -78 - 20 °C

With triethylsilane; dmap; thionyl chloride; boron trifluoride diethyl etherate; lithium triethylborohydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo0495438

Reference yield:

: (2S,3R)-5-Oxo-3-(4-trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester

: 528607-37-6
(2S,3R)-3-(4-Trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP / acetonitrile / 20 °C

2: lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C

3: triethylsilane; boron trifluoride etherate / CH₂Cl₂ / 1 h / -78 - 20 °C

With triethylsilane; dmap; boron trifluoride diethyl etherate; lithium triethylborohydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo0495438