(4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene

Base Information

Chemical Name:(4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene
CAS No.:159351-02-7
Molecular Formula:C₂₇H₃₈O₇
Molecular Weight:474.595
Hs Code.:

Synonyms:(4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene

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Chemical Property of (4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene

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Technology Process of (4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene

There total 7 articles about (4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 21852-32-4
4-bromomethyl-1,2-dimethoxybenzene

: 159351-01-6
(4S,6R,7R)-6-(4-Methoxy-benzyloxy)-7-methoxymethoxy-oct-1-en-4-ol

: 159351-02-7
(4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1055/s-1994-25589

Reference yield:

: 141076-92-8
(R)-2-Methoxymethoxy-propionaldehyde

: 159351-02-7
(4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene

Guidance literature:: Multi-step reaction with 5 steps

1: MgBr*Et₂O / CH₂Cl₂ / 15 min then -78 deg C and 16 h, to -20 deg C

2: 69 percent / t-BuOK / tetrahydrofuran / 4 h / Ambient temperature

3: 62 percent / NaIO₄, OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 3 h / Ambient temperature

4: 97 percent / MgBr*Et₂O / CH₂Cl₂ / 15 min then -78 deg C and 18 h, to -20 deg C

5: 79 percent / t-BuOK / tetrahydrofuran / 2 h / Ambient temperature

With sodium periodate; osmium(VIII) oxide; potassium tert-butylate; magnesium bromide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1055/s-1994-25589

Reference yield:

: 159350-97-7
(R)-2-(methoxymethoxy)-1-propanol

: 159351-02-7
(4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) (COCl), DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C 2.) CH₂Cl₂, -78 deg C

2: MgBr*Et₂O / CH₂Cl₂ / 15 min then -78 deg C and 16 h, to -20 deg C

3: 69 percent / t-BuOK / tetrahydrofuran / 4 h / Ambient temperature

4: 62 percent / NaIO₄, OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 3 h / Ambient temperature

5: 97 percent / MgBr*Et₂O / CH₂Cl₂ / 15 min then -78 deg C and 18 h, to -20 deg C

6: 79 percent / t-BuOK / tetrahydrofuran / 2 h / Ambient temperature

With sodium periodate; osmium(VIII) oxide; potassium tert-butylate; dimethyl sulfoxide; triethylamine; magnesium bromide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1055/s-1994-25589