(R)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-phenyl-propan-1-one

Base Information

• Chemical Name: (R)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-phenyl-propan-1-one
• CAS No.: 195832-80-5
• Molecular Formula: C₁₉H₂₅NO₃S
• Molecular Weight: 347.478

Synonyms:(R)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-phenyl-propan-1-one

Chemical Property of (R)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-phenyl-propan-1-one

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Technology Process of (R)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-phenyl-propan-1-one

There total 1 articles about (R)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-phenyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(2R)-N-(phenylacetyl)bornane-10,2-sultam (129505-03-9) + methyl iodide (74-88-4) → (R)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-phenyl-propan-1-one (195832-80-5)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; hexane; at -70 - -50 ℃;

DOI:10.1002/hlca.19970800502

Reference yield: 96.0%

phenylmethanethiol (100-53-8) + (R)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-phenyl-propan-1-one (195832-80-5) → S-benzyl (R)-2-phenylpropylthioester (195832-90-7)

Guidance literature:

With n-butyllithium; trimethylaluminum; In diethyl ether; hexane; toluene; at 0 ℃; for 3.75h;

DOI:10.1002/hlca.19970800502

Reference yield:

(R)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-phenyl-propan-1-one (195832-80-5) → (S)-methyldesoxybenzoin (951-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / BuLi, Me₃Al / diethyl ether; hexane; toluene / 3.75 h / 0 °C

2: Fe(acac)3 / tetrahydrofuran; diethyl ether / 4 h / -20 °C

With n-butyllithium; trimethylaluminum; iron(III)-acetylacetonate; In tetrahydrofuran; diethyl ether; hexane; toluene;

DOI:10.1002/hlca.19970800502

upstream raw materials:

(2R)-N-(phenylacetyl)bornane-10,2-sultam

methyl iodide

Downstream raw materials:

S-benzyl (R)-2-phenylpropylthioester

(S)-methyldesoxybenzoin

1,2-diphenylpropan-1-one

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