2-Bromo-3-ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole

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Chemical Name:2-Bromo-3-ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole
CAS No.:208753-50-8
Molecular Formula:C₂₁H₁₇BrF₃N₃O₂S
Molecular Weight:512.35
Hs Code.:

Synonyms:2-Bromo-3-ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole

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Chemical Property of 2-Bromo-3-ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole

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Technology Process of 2-Bromo-3-ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole

There total 3 articles about 2-Bromo-3-ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 208753-49-5
4-Ethyl-2-(toluene-4-sulfonyl)-3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole

: 208753-50-8
2-Bromo-3-ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole

Guidance literature:: With phenyltrimethylammonium tribromide; In dichloromethane; at 0 ℃; for 0.166667h; Yield given;
DOI:10.1246/cl.1998.455

Reference yield:

: 128886-88-4
4-<3-trifluoromethyl-3H-diazirin-3-yl>benzaldehyde

: 208753-50-8
2-Bromo-3-ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / methanol / 18 h / 20 °C

2: 1.) Et₃N; 2.) DBU / 1.) CH₂Cl₂, r.t., 18 h; 2.) MeCN, r.t.

3: PhMe₃NBr₃ / CH₂Cl₂ / 0.17 h / 0 °C

With potassium hydroxide; phenyltrimethylammonium tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In methanol; dichloromethane;
DOI:10.1246/cl.1998.455

Reference yield:

: 208753-46-2
2-Nitro-1-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-butan-1-ol

: 208753-50-8
2-Bromo-3-ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₃N; 2.) DBU / 1.) CH₂Cl₂, r.t., 18 h; 2.) MeCN, r.t.

2: PhMe₃NBr₃ / CH₂Cl₂ / 0.17 h / 0 °C

With phenyltrimethylammonium tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane;
DOI:10.1246/cl.1998.455