3-Ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1,5-dihydro-pyrrol-2-one

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Chemical Name:3-Ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1,5-dihydro-pyrrol-2-one
CAS No.:208753-51-9
Molecular Formula:C₂₁H₁₈F₃N₃O₃S
Molecular Weight:449.453
Hs Code.:

Synonyms:3-Ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1,5-dihydro-pyrrol-2-one

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Chemical Property of 3-Ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1,5-dihydro-pyrrol-2-one

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Technology Process of 3-Ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1,5-dihydro-pyrrol-2-one

There total 4 articles about 3-Ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1,5-dihydro-pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 208753-50-8
2-Bromo-3-ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1H-pyrrole

: 208753-51-9
3-Ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1,5-dihydro-pyrrol-2-one

Guidance literature:: With water; trifluoroacetic acid; at 25 ℃; for 48h;
DOI:10.1246/cl.1998.455

Reference yield:

: 128886-88-4
4-<3-trifluoromethyl-3H-diazirin-3-yl>benzaldehyde

: 208753-51-9
3-Ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1,5-dihydro-pyrrol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: KOH / methanol / 18 h / 20 °C

2: 1.) Et₃N; 2.) DBU / 1.) CH₂Cl₂, r.t., 18 h; 2.) MeCN, r.t.

3: PhMe₃NBr₃ / CH₂Cl₂ / 0.17 h / 0 °C

4: 72 percent / TFA, H₂O / 48 h / 25 °C

With potassium hydroxide; water; phenyltrimethylammonium tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1246/cl.1998.455

Reference yield:

: 208753-46-2
2-Nitro-1-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-butan-1-ol

: 208753-51-9
3-Ethyl-5-(toluene-4-sulfonyl)-4-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-1,5-dihydro-pyrrol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N; 2.) DBU / 1.) CH₂Cl₂, r.t., 18 h; 2.) MeCN, r.t.

2: PhMe₃NBr₃ / CH₂Cl₂ / 0.17 h / 0 °C

3: 72 percent / TFA, H₂O / 48 h / 25 °C

With water; phenyltrimethylammonium tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1246/cl.1998.455