(S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dimethoxyphenyl)isonicotinamide

Base Information

Chemical Name:(S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dimethoxyphenyl)isonicotinamide
CAS No.:1448440-57-0
Molecular Formula:C₂₁H₂₂N₄O₄
Molecular Weight:394.43
Hs Code.:

Synonyms:(S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dimethoxyphenyl)isonicotinamide

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Chemical Property of (S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dimethoxyphenyl)isonicotinamide

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Technology Process of (S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dimethoxyphenyl)isonicotinamide

There total 3 articles about (S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dimethoxyphenyl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1448440-57-0
(S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dimethoxyphenyl)isonicotinamide

Guidance literature:: With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.5h;

With triethylamine; In tetrahydrofuran; dichloromethane; for 2h;

Reference yield: 43.0%

: 1428264-81-6
(S)-1-(2-aminoacetyl)pyrrolidine-2-carbonitrile 4-methylbenzenesulfonate

: 1226337-16-1
2-(3,4-dimethoxyphenyl)isonicotinic acid

: 1448440-57-0
(S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dimethoxyphenyl)isonicotinamide

Guidance literature:: 2-(3,4-dimethoxyphenyl)isonicotinic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.25h;

(S)-1-(2-aminoacetyl)pyrrolidine-2-carbonitrile 4-methylbenzenesulfonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm500031w

Reference yield:

: 66572-56-3
2-bromoisonicotinic acid

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1448440-57-0
(S)-N-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dimethoxyphenyl)isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / Inert atmosphere

1.2: 95 °C / Inert atmosphere

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h

2.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jm500031w