Levomepromazine

Base Information

• Chemical Name: Levomepromazine
• CAS No.: 60-99-1
• Molecular Formula: C19H24N2OS
• Molecular Weight: 328.478
• Hs Code.: 2934302300
• European Community (EC) Number: 200-495-5,230-412-8
• UNII: 9G0LAW7ATQ
• DSSTox Substance ID: DTXSID1023289
• Nikkaji Number: J76.892H
• Wikipedia: Levomepromazine
• Wikidata: Q417204
• NCI Thesaurus Code: C66118
• Metabolomics Workbench ID: 43538
• ChEMBL ID: CHEMBL1764
• Mol file: 60-99-1.mol

Synonyms:Levomeprazin;Levomepromazine;Levopromazine;Methotrimeprazine;Tisercin;Tizercine;Tizertsin

Chemical Property of Levomepromazine

Chemical Property:

• Vapor Pressure: 6.22E-09mmHg at 25°C
• Melting Point: 117°C
• Refractive Index: 1.594
• Boiling Point: 468 °C at 760 mmHg
• Flash Point: 236.8 °C
• PSA: 41.01000
• Density: 1.125 g/cm³
• LogP: 4.56060
• Water Solubility.: 20mg/L(25 oC)
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 328.16093457
• Heavy Atom Count: 23
• Complexity: 378

Purity/Quality:

99.9% ^*data from raw suppliers

(R)-Methotrimeprazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C
• Isomeric SMILES: C[C@@H](CN1C2=CC=CC=C2SC3=C1C=C(C=C3)OC)CN(C)C
• Recent ClinicalTrials: Pharmacovigilance in Gerontopsychiatric Patients
• Recent EU Clinical Trials: Evaluation of the necessity of a pharmacological treatment with antipsychotics for the prevention of relapse in long-term stabilized schizophrenic patients: a randomized, single-blind, longitudinal trial
• Uses: Analgesic (R)-Methotrimeprazine acts as an analgesic agent.
• Therapeutic Function: Analgesic

Technology Process of Levomepromazine

There total 2 articles about Levomepromazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methotrimeprazine (851-68-3) → levomepromazine (60-99-1)

Guidance literature:

With D-tartaric acid;

Reference yield:

(S)-γ-(2-methoxy-phenothiazin-10-yl)-isobutylamin; hydrochloride (98284-19-6) → levomepromazine (60-99-1)

Guidance literature:

anschliessende Hydrierung an Platin;

upstream raw materials:

Methotrimeprazine

(S)-γ-(2-methoxy-phenothiazin-10-yl)-isobutylamin; hydrochloride