CAS No.60-99-1,(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Suppliers

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Basic Information

Molecular Structure:
CAS No.:	60-99-1
Name:	(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

Formula:	C₁₉H₂₄N₂OS
Molecular Weight:	328.478
Synonyms:	10H-Phenothiazine-10-propanamine,2-methoxy-N,N,b-trimethyl-,(R)-;Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-, (-)-(8CI);2-Methoxytrimeprazine;7044 R.P.;CL 36467;CL 39743;Hirnamin;Levomeprazine;Levomepromazin;Levomepromazine;Levopromazine;Levoprome;Levopromethazine;Levotomin;Mepromazine;Methotrimeprazine;NSC 226516;Neozine;Nirvan;Nozinan;Nozinane;RP 7044;SKF 5116;Sinogan;Sinogan-Debil;Tisercin;XP 03;
EINECS:	200-495-5
Density:	1.125 g/cm³
Melting Point:	117°C
Boiling Point:	468 °C at 760 mmHg
Flash Point:	236.8 °C
Solubility:	20mg/L(25 oC)
Hazard Symbols:	Xn
Risk Codes:	20/21/22
Safety:	36
Transport Information:	UN 3249
PSA:	41.01000
LogP:	4.56060

Synthetic route

: 851-68-3
Methotrimeprazine

: 60-99-1
levomepromazine

Conditions

Conditions	Yield
With D-tartaric acid

: 98284-19-6
(S)-γ-(2-methoxy-phenothiazin-10-yl)-isobutylamin; hydrochloride

aqueous methanol. formaldehyde: aqueous methanol. formaldehyde

: 60-99-1
levomepromazine

Conditions

Conditions	Yield
anschliessende Hydrierung an Platin;

Raw Materials

1771-18-2

851-68-3

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Specification

This chemical is called 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,β-trimethyl-, (βR)-, and its CAS registry number is 60-99-1. With the molecular formula of C₁₉H₂₄N₂OS, its classification codes are Analgesic; Analgesic [central nervous system depressant]; Analgesics, non-narcotic; Central Nervous System Depressants; Dopamine Agents; Dopamine antagonists; Drug / Therapeutic Agent; Human Data; Neurotransmitter Agents; Peripheral Nervous System Agents; Psychotropic Drugs; Sensory System Agents; Tranquilizing Agents. Additionally, its product categories are Intermediates & Fine Chemicals; Pharmaceuticals. It's a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine.

Other characteristics of the 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,β-trimethyl-, (βR)- can be summarised as followings: (1)ACD/LogP: 4.94; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.91; (4)ACD/LogD (pH 7.4): 3.04; (5)ACD/BCF (pH 5.5): 3.15; (6)ACD/BCF (pH 7.4): 42.18; (7)ACD/KOC (pH 5.5): 10.94; (8)ACD/KOC (pH 7.4): 146.34; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 41.01 Å²; (13)Index of Refraction: 1.594; (14)Molar Refractivity: 99.12 cm³; (15)Molar Volume: 291.8 cm³; (16)Polarizability: 39.29×10^-24cm³; (17)Surface Tension: 42.7 dyne/cm; (18)Density: 1.125 g/cm³; (19)Flash Point: 236.8 °C; (20)Enthalpy of Vaporization: 73.01 kJ/mol; (21)Boiling Point: 468 °C at 760 mmHg; (22)Vapour Pressure: 6.22E-09 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following: This chemical is harmful by inhalation, in contacting with skin and if swallowed. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: O(c2cc1N(c3c(Sc1cc2)cccc3)C[C@H](C)CN(C)C)C
2.InChI: InChI=1/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3/t14-/m1/s1
3.InChIKey: VRQVVMDWGGWHTJ-CQSZACIVBE

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	100mg/kg (100mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
man	TDLo	oral	7143ug/kg (7.143mg/kg)	BLOOD: THROMBOCYTOPENIA	Human Psychopharmacology. Vol. 9, Pg. 299, 1994.
mouse	LD50	intraperitoneal	58500ug/kg (58.5mg/kg)		Farmakologiya i Toksikologiya Vol. 53(4), Pg. 19, 1990.
mouse	LD50	intravenous	39mg/kg (39mg/kg)		Proceedings of the European Society for the Study of Drug Toxicity. Vol. 9, Pg. 159, 1968.
mouse	LD50	oral	370mg/kg (370mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 841, 1965.
mouse	LD50	subcutaneous	300mg/kg (300mg/kg)		Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
rat	LD50	oral	1100mg/kg (1100mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 31, 1972.
rat	LD50	subcutaneous	45mg/kg (45mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 31, 1972.