(1R,2R)-N,N'-Bis-((S)-2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine

Base Information

Chemical Name:(1R,2R)-N,N'-Bis-((S)-2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine
CAS No.:218933-95-0
Molecular Formula:C₂₆H₃₈N₄O₂
Molecular Weight:438.613
Hs Code.:

Synonyms:(1R,2R)-N,N'-Bis-((S)-2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine

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Chemical Property of (1R,2R)-N,N'-Bis-((S)-2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine

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Technology Process of (1R,2R)-N,N'-Bis-((S)-2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine

There total 2 articles about (1R,2R)-N,N'-Bis-((S)-2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 218933-95-0
(1R,2R)-N,N'-Bis-((S)-2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / CH₂Cl₂ / 0 °C

2.1: CeCl₃ / tetrahydrofuran; hexane / 2 h / 0 °C

2.2: tetrahydrofuran; hexane / 15 h / -100 - 20 °C

With cerium(III) chloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-2002-35628

Reference yield:

: phenylmagnesium bromide

: 184377-96-6
(2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine

: 218933-95-0
(1R,2R)-N,N'-Bis-((S)-2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine

: N,N'-bis-(2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine

Guidance literature:: phenylmagnesium bromide; With cerium(III) chloride; In tetrahydrofuran; hexane; at 0 ℃; for 2h;

(2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine; In tetrahydrofuran; hexane; at -100 - 20 ℃; for 15h; Title compound not separated from byproducts;
DOI:10.1055/s-2002-35628