(2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine

Base Information

• Chemical Name: (2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine
• CAS No.: 184377-96-6
• Molecular Formula: C₁₄H₂₆N₄O₂
• Molecular Weight: 282.386
• Mol file: 184377-96-6.mol

Synonyms:(2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine

Chemical Property of (2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine

There total 1 articles about (2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Glyoxal (131543-46-9,107-22-2) + (S)-1-amino-2-(methoxymethyl)pyrrolidine (59983-39-0,187035-29-6) → (2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine (184377-96-6)

Guidance literature:

In dichloromethane; at 0 ℃;

DOI:10.1055/s-2002-35628

Reference yield:

phenylmagnesium bromide (1589-82-8) + (2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine (184377-96-6) → N,N'-bis-(2-methoxymethyl-pyrrolidin-1-yl)-1,4-diphenyl-butane-2,3-diamine + N,N'-bis-(2-methoxymethyl-pyrrolidin-1-yl)-1,4-diphenyl-butane-2,3-diamine

Guidance literature:

phenylmagnesium bromide; With cerium(III) chloride; In tetrahydrofuran; at 0 ℃; for 2h;

(2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine; In tetrahydrofuran; hexane; at -100 - 20 ℃; for 15h;

DOI:10.1055/s-2002-35628

Reference yield:

phenylmagnesium bromide + (2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine (184377-96-6) → (1R,2R)-N,N'-Bis-((S)-2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine (218933-95-0) + N,N'-bis-(2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine

Guidance literature:

phenylmagnesium bromide; With cerium(III) chloride; In tetrahydrofuran; hexane; at 0 ℃; for 2h;

(2S,2'S)-(-)-2-{[2-(methoxymethyl)pyrrolidine-1-yl]imino}ethylidene-2-(methoxymethyl)pyrrolidine-1-ylamine; In tetrahydrofuran; hexane; at -100 - 20 ℃; for 15h; Title compound not separated from byproducts;

DOI:10.1055/s-2002-35628

upstream raw materials:

Glyoxal

(S)-1-amino-2-(methoxymethyl)pyrrolidine

Downstream raw materials:

(1R,2R)-N,N'-Bis-((S)-2-methoxymethyl-pyrrolidin-1-yl)-1,2-diphenyl-ethane-1,2-diamine