diethyl 2-acetyl-5-hydroxyisophthalate

Base Information

• Chemical Name: diethyl 2-acetyl-5-hydroxyisophthalate
• CAS No.: 1192159-40-2
• Molecular Formula: C₁₄H₁₆O₆
• Molecular Weight: 280.277
• Mol file: 1192159-40-2.mol

Synonyms:diethyl 2-acetyl-5-hydroxyisophthalate

Chemical Property of diethyl 2-acetyl-5-hydroxyisophthalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of diethyl 2-acetyl-5-hydroxyisophthalate

There total 2 articles about diethyl 2-acetyl-5-hydroxyisophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

diethyl 4-oxo-4H-pyran-2,6-dicarboxylate (725-92-8) + acetylacetone (123-54-6,81235-32-7) → diethyl 2-acetyl-5-hydroxyisophthalate (1192159-40-2)

Guidance literature:

diethyl 4-oxo-4H-pyran-2,6-dicarboxylate; acetylacetone; With potassium tert-butylate; In tert-butyl alcohol; at 120 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In water; tert-butyl alcohol; for 1h; Reflux;

DOI:10.1002/jlcr.1776

Reference yield:

C16H18O7 → diethyl 2-acetyl-5-hydroxyisophthalate (1192159-40-2)

Guidance literature:

With hydrogenchloride; water; In tert-butyl alcohol; at 120 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1016/j.tet.2009.07.083

upstream raw materials:

diethyl 4-oxo-4H-pyran-2,6-dicarboxylate

acetylacetone

Refernces

• 1、 Marshall, Laura J.,Cable, Karl M.,Botting, Nigel P.. "The synthesis of substituted phenols from pyranone precursors". experimental part. p. 8165 - 8170. Retrieved 2009/12/26.