5'-O-(4,4'-dimethoxytrityl)-3'-O-[3-[(2-cyanoethyl)-N,N-diethylphosphoramidothioyl]prop-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-3'-O-[3-[(2-cyanoethyl)-N,N-diethylphosphoramidothioyl]prop-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine
CAS No.:1233482-85-3
Molecular Formula:C₄₇H₆₅N₅O₁₀P₂S
Molecular Weight:954.074
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-O-[3-[(2-cyanoethyl)-N,N-diethylphosphoramidothioyl]prop-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[3-[(2-cyanoethyl)-N,N-diethylphosphoramidothioyl]prop-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[3-[(2-cyanoethyl)-N,N-diethylphosphoramidothioyl]prop-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-O-[3-[(2-cyanoethyl)-N,N-diethylphosphoramidothioyl]prop-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1233482-65-9
O-(1-hydroxypropyl)-O-(2-cyanoethyl)-N,N-diethyl phosphoramidothioate

: 104655-84-7
5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite

: 1233482-85-3
5'-O-(4,4'-dimethoxytrityl)-3'-O-[3-[(2-cyanoethyl)-N,N-diethylphosphoramidothioyl]prop-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Guidance literature:: With 1H-tetrazole; In acetonitrile; at 25 ℃; for 3h; Inert atmosphere;
DOI:10.1039/b9nj00692c

Reference yield:

: C₃₁H₃₉N₂O₅P

: 1233482-85-3
5'-O-(4,4'-dimethoxytrityl)-3'-O-[3-[(2-cyanoethyl)-N,N-diethylphosphoramidothioyl]prop-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur / dichloromethane / 16 h / 25 °C / Inert atmosphere

2: acetic acid / water / 3 h / 25 °C / Inert atmosphere

3: 1H-tetrazole / acetonitrile / 3 h / 25 °C / Inert atmosphere

With 1H-tetrazole; sulfur; acetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1039/b9nj00692c

Reference yield:

: C₃₁H₃₉N₂O₅PS

: 1233482-85-3
5'-O-(4,4'-dimethoxytrityl)-3'-O-[3-[(2-cyanoethyl)-N,N-diethylphosphoramidothioyl]prop-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / water / 3 h / 25 °C / Inert atmosphere

2: 1H-tetrazole / acetonitrile / 3 h / 25 °C / Inert atmosphere

With 1H-tetrazole; acetic acid; In water; acetonitrile;
DOI:10.1039/b9nj00692c