N-(2-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)-7-methoxy-2-oxo-2H-chromene-3-carboxamide

Base Information

• Chemical Name: N-(2-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)-7-methoxy-2-oxo-2H-chromene-3-carboxamide
• CAS No.: 812653-52-4
• Molecular Formula: C₂₆H₂₄N₂O₆
• Molecular Weight: 460.486
• Mol file: 812653-52-4.mol

Synonyms:N-(2-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)-7-methoxy-2-oxo-2H-chromene-3-carboxamide

Chemical Property of N-(2-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)-7-methoxy-2-oxo-2H-chromene-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)-7-methoxy-2-oxo-2H-chromene-3-carboxamide

There total 8 articles about N-(2-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)-7-methoxy-2-oxo-2H-chromene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

7-methoxycoumarin-3-carboxylic acid (20300-59-8) + 1-(β-aminoethyl)-3-(benzyloxy)-2-methyl-4(1H)-pyridinone (149457-89-6) → N-(2-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)-7-methoxy-2-oxo-2H-chromene-3-carboxamide (812653-52-4)

Guidance literature:

7-methoxycoumarin-3-carboxylic acid; With dmap; 2-mercaptothiazoline; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

1-(β-aminoethyl)-3-(benzyloxy)-2-methyl-4(1H)-pyridinone; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2020.115550

Reference yield:

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) → N-(2-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)-7-methoxy-2-oxo-2H-chromene-3-carboxamide (812653-52-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / piperidine; glacial acetic acid / ethanol / 3 h / Heating

2: 85 percent / aq. NaOH / ethanol / 0.25 h / Heating

3: dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂

4: 2.61 g / CH₂Cl₂

With piperidine; dmap; sodium hydroxide; acetic acid; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/jm049751s

Reference yield:

Maltol (118-71-8) → N-(2-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)-7-methoxy-2-oxo-2H-chromene-3-carboxamide (812653-52-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / aq. NaOH / methanol / Heating

2: 88 percent / H₂O / 70 °C

3: 2.61 g / CH₂Cl₂

With sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1021/jm049751s

upstream raw materials:

2-Hydroxy-4-methoxybenzaldehyde

Maltol

3-O-benzylmaltol

7-methoxycoumarin-3-carboxylic acid ethyl ester