6-(benzyloxy(tert-butoxycarbonyl)amino)hexanoic acid

Base Information

• Chemical Name: 6-(benzyloxy(tert-butoxycarbonyl)amino)hexanoic acid
• CAS No.: 1628321-44-7
• Molecular Formula: C₁₈H₂₇NO₅
• Molecular Weight: 337.416
• Mol file: 1628321-44-7.mol

Synonyms:6-(benzyloxy(tert-butoxycarbonyl)amino)hexanoic acid

Chemical Property of 6-(benzyloxy(tert-butoxycarbonyl)amino)hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(benzyloxy(tert-butoxycarbonyl)amino)hexanoic acid

There total 4 articles about 6-(benzyloxy(tert-butoxycarbonyl)amino)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C20H31NO5 (1628321-41-4) → 6-(benzyloxy(tert-butoxycarbonyl)amino)hexanoic acid (1628321-44-7)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

DOI:10.1002/chem.201304115

Reference yield: 70.0%

6-bromohexanoic acid (4224-70-8) + tert-butyl N-(benzyloxy)carbamate (79722-21-7) → 6-(benzyloxy(tert-butoxycarbonyl)amino)hexanoic acid (1628321-44-7)

Guidance literature:

tert-butyl N-(benzyloxy)carbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

6-bromohexanoic acid; In N,N-dimethyl-formamide; at 0 - 70 ℃; for 19h; Inert atmosphere;

DOI:10.1016/j.tet.2015.10.031

Reference yield:

tert-butyl N-(benzyloxy)carbamate (79722-21-7) → 6-(benzyloxy(tert-butoxycarbonyl)amino)hexanoic acid (1628321-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice

1.2: 14 h / 65 °C / Inert atmosphere

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 4 h / 20 °C

With water; sodium hydride; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/chem.201304115

upstream raw materials:

tert-butyl N-(benzyloxy)carbamate

6-bromo-hexanoic acid ethyl ester

C₂₀H₃₁NO₅

6-bromohexanoic acid

Downstream raw materials:

C₃₁H₄₄N₂O₇

C₃₆H₄₇N₃O₅

C₅₄H₇₀N₄O₈

C₅₂H₆₆N₄O₈