N-cyclopropyl-5(4-[[2-(4-fluorophenyl)ethyl]amino]-6-methoxy-1,3,5-triazin-2-yl)-2-methoxybenzenesulfonamide

Base Information

• Chemical Name: N-cyclopropyl-5(4-[[2-(4-fluorophenyl)ethyl]amino]-6-methoxy-1,3,5-triazin-2-yl)-2-methoxybenzenesulfonamide
• CAS No.: 1443151-92-5
• Molecular Formula: C₂₂H₂₄FN₅O₄S
• Molecular Weight: 473.528
• Mol file: 1443151-92-5.mol

Synonyms:N-cyclopropyl-5(4-[[2-(4-fluorophenyl)ethyl]amino]-6-methoxy-1,3,5-triazin-2-yl)-2-methoxybenzenesulfonamide

Chemical Property of N-cyclopropyl-5(4-[[2-(4-fluorophenyl)ethyl]amino]-6-methoxy-1,3,5-triazin-2-yl)-2-methoxybenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclopropyl-5(4-[[2-(4-fluorophenyl)ethyl]amino]-6-methoxy-1,3,5-triazin-2-yl)-2-methoxybenzenesulfonamide

There total 5 articles about N-cyclopropyl-5(4-[[2-(4-fluorophenyl)ethyl]amino]-6-methoxy-1,3,5-triazin-2-yl)-2-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-cyclopropyl-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide (1226903-49-6) + 4-chloro-N-[2-(4-fluorophenyl)ethyl]-6-methoxy-1,3,5-triazin-2-amine (1283063-82-0) → N-cyclopropyl-5(4-[[2-(4-fluorophenyl)ethyl]amino]-6-methoxy-1,3,5-triazin-2-yl)-2-methoxybenzenesulfonamide (1443151-92-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; water; at 20 ℃;

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → N-cyclopropyl-5(4-[[2-(4-fluorophenyl)ethyl]amino]-6-methoxy-1,3,5-triazin-2-yl)-2-methoxybenzenesulfonamide (1443151-92-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuryl dichloride / 1 h / 20 °C

2: dichloromethane / 72 h / 20 °C

3: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 80 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,2-dimethoxyethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuryl dichloride; potassium acetate; caesium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

5-bromo-2-methoxybenzenesulfonyl chloride (23095-05-8) → N-cyclopropyl-5(4-[[2-(4-fluorophenyl)ethyl]amino]-6-methoxy-1,3,5-triazin-2-yl)-2-methoxybenzenesulfonamide (1443151-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 72 h / 20 °C

2: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 80 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,2-dimethoxyethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; caesium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

1-bromo-4-methoxy-benzene

5-bromo-2-methoxybenzenesulfonyl chloride

5-bromo-N-cyclopropyl-2-(methyloxy)benzenesulfonamide

N-cyclopropyl-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide

Refernces