(5R,6R)-5-(4-methylphenyl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole

Base Information

Chemical Name:(5R,6R)-5-(4-methylphenyl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole
CAS No.:1430205-90-5
Molecular Formula:C₂₄H₂₂O₄S
Molecular Weight:406.502
Hs Code.:

Synonyms:(5R,6R)-5-(4-methylphenyl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole

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Chemical Property of (5R,6R)-5-(4-methylphenyl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole

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Technology Process of (5R,6R)-5-(4-methylphenyl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole

There total 3 articles about (5R,6R)-5-(4-methylphenyl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1430205-69-8
(5R,6R)-5-(4-methylphenyl)-6-(phenylthio)-5,6,7,-8-tetrahydronaphtho[2,3-d]-1,3-dioxole

: 1430205-90-5
(5R,6R)-5-(4-methylphenyl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ja401867b

Reference yield:

: 5-(4-methylphenyl)-6-(phenylthio)-5,6,7,-8-tetrahydronaphtho[2,3-d]-1,3-dioxole

: 1430205-90-5
(5R,6R)-5-(4-methylphenyl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole

: (5S,6S)-5-(4-methylphenyl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h; Overall yield = 94%; Overall yield = 130 mg; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jo4023765

Reference yield:

: 14204-27-4
N-phenylthiophthalimide

: 1430205-90-5
(5R,6R)-5-(4-methylphenyl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole

Guidance literature:: Multi-step reaction with 2 steps

1: C₃₀H₃₆N₃PSe; ethanesulfonic acid / dichloromethane / 48 h / -20 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With ethanesulfonic acid; C₃₀H₃₆N₃PSe; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/ja401867b