(4-chlorophenyl)(6-methoxy-3-(trimethylsilyl)benzo[b]thiophen-2-yl)methanone

Base Information

Chemical Name:(4-chlorophenyl)(6-methoxy-3-(trimethylsilyl)benzo[b]thiophen-2-yl)methanone
CAS No.:1374636-61-9
Molecular Formula:C₁₉H₁₉ClO₂SSi
Molecular Weight:374.963
Hs Code.:

Synonyms:(4-chlorophenyl)(6-methoxy-3-(trimethylsilyl)benzo[b]thiophen-2-yl)methanone

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Chemical Property of (4-chlorophenyl)(6-methoxy-3-(trimethylsilyl)benzo[b]thiophen-2-yl)methanone

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Technology Process of (4-chlorophenyl)(6-methoxy-3-(trimethylsilyl)benzo[b]thiophen-2-yl)methanone

There total 4 articles about (4-chlorophenyl)(6-methoxy-3-(trimethylsilyl)benzo[b]thiophen-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1374636-54-0
(((2-bromo-5-methoxyphenyl)thio)ethynyl)trimethylsilane

: 122-01-0
4-chloro-benzoyl chloride

: 1374636-61-9
(4-chlorophenyl)(6-methoxy-3-(trimethylsilyl)benzo[b]thiophen-2-yl)methanone

Guidance literature:: (((2-bromo-5-methoxyphenyl)thio)ethynyl)trimethylsilane; With TurboGrignard; In tetrahydrofuran; at 25 ℃; for 4h; Inert atmosphere;

With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; at 25 ℃; for 24h; Inert atmosphere;

4-chloro-benzoyl chloride; In tetrahydrofuran; at -20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201106734

Reference yield:

: 1374636-44-8
1,2-bis(2-bromo-5-methoxyphenyl)disulfane

: 1374636-61-9
(4-chlorophenyl)(6-methoxy-3-(trimethylsilyl)benzo[b]thiophen-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine / dichloromethane / Inert atmosphere

2.1: TurboGrignard / tetrahydrofuran / 0.5 h / -30 °C / Inert atmosphere

2.2: -50 - 20 °C / Inert atmosphere

3.1: TurboGrignard / tetrahydrofuran / 4 h / 25 °C / Inert atmosphere

3.2: 24 h / 25 °C / Inert atmosphere

3.3: 2 h / -20 °C / Inert atmosphere

With TurboGrignard; iodine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201106734

Reference yield:

: 1374636-48-2
S-(2-bromo-5-methoxyphenyl)benzenesulfonothioate

: 1374636-61-9
(4-chlorophenyl)(6-methoxy-3-(trimethylsilyl)benzo[b]thiophen-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / 0.5 h / -30 °C / Inert atmosphere

1.2: -50 - 20 °C / Inert atmosphere

2.1: TurboGrignard / tetrahydrofuran / 4 h / 25 °C / Inert atmosphere

2.2: 24 h / 25 °C / Inert atmosphere

2.3: 2 h / -20 °C / Inert atmosphere

With TurboGrignard; In tetrahydrofuran;
DOI:10.1002/anie.201106734