1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one

Base Information

• Chemical Name: 1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one
• CAS No.: 780020-06-6
• Molecular Formula: C₂₃H₂₆FNO
• Molecular Weight: 351.464
• Mol file: 780020-06-6.mol

Synonyms:1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one

Chemical Property of 1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one

There total 8 articles about 1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(1R,3S,5S)-8-{3-[2-(4-Fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-3-phenyl-8-aza-bicyclo[3.2.1]octane → 1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one (780020-06-6)

Guidance literature:

With hydrogenchloride; for 0.333333h; Heating;

DOI:10.1021/jm970326r

Reference yield: 11.0%

3-phenyl-8-aza-bicyclo[3.2.1]octane (669002-98-6) + 4-(4-fluorophenyl)-4-oxo-n-butyl chloride (3874-54-2,41167-07-1) → 1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one (780020-06-6)

Guidance literature:

With potassium carbonate; potassium iodide; In 1,2-dimethoxyethane; for 12h; Heating;

DOI:10.1016/j.bmcl.2004.09.046

Reference yield:

N-carbethoxytropinone (32499-64-2) → 1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one (780020-06-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 42 percent / diethyl ether / 12 h / Heating

2: 73 percent / KOH; ethylene glycol / 150 °C

3: 100 percent / AcOH; HCl / 2.5 h / Heating

4: 100 percent / H₂ / Pd/C / methanol / 1.5 h / 20 °C / 3361.46 Torr

5: 11 percent / KI; K₂CO₃ / 1,2-dimethoxy-ethane / 12 h / Heating

With hydrogenchloride; potassium hydroxide; hydrogen; potassium carbonate; ethylene glycol; acetic acid; potassium iodide; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; diethyl ether;

DOI:10.1016/j.bmcl.2004.09.046

upstream raw materials:

3-phenyl-8-aza-bicyclo[3.2.1]octane

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

N-carbethoxytropinone

(3-endo)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octan-3-ol