669002-98-6

Upstream product

• 861853-60-3 C₁₆H₂₁NO₂ 
• 676366-91-9 tert-butyl 3-phenyl-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 83393-32-2 8-ethoxycarbonyl-3β-(4-chlorophenyl)-3α-hydroxy-8-azabicyclo[3.2.1]octane 
• 637311-69-4 (3-endo)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octan-3-ol 
• 32499-64-2 N-carbethoxytropinone 
• 912641-08-8 3-(4-chloro-phenyl)-8-aza-bicyclo[3.2.1]oct-2-ene 

Downstream Products

• 780020-06-6 1-(4-Fluoro-phenyl)-4-((1R,3S,5S)-3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-butan-1-one 

Relevant academic research and scientific papers

2,6-Disubstituted piperiddines as modulators

The present invention is further directed to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R16, R17, R18, R19, R20, R21 and R22 are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.

Haloperidol: Towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors

An attempt to understand the pharmacophore-relevant position of the alcoholic moiety in haloperidol and the contributions of other pharmacophoric elements led to the re-synthesis of its tropane analogue (compound 2). An analysis of the binding data sugges

Benzimidazolidinone derivatives as muscarinic agents

Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.