phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl)methanone

Base Information

• Chemical Name: phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl)methanone
• CAS No.: 1440956-21-7
• Molecular Formula: C₁₈H₂₆BNO₃
• Molecular Weight: 315.22
• Mol file: 1440956-21-7.mol

Synonyms:phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl)methanone

Chemical Property of phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl)methanone

There total 1 articles about phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

C19H21NO4S + bis(pinacol)diborane (73183-34-3) → phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl)methanone (1440956-21-7)

Guidance literature:

With silver(I) pentafluoropropionate; lithium tert-butoxide; In 1,4-dioxane; at 60 ℃; for 24h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/cjoc.201800500

Reference yield: 88.0%

phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl)methanone (1440956-21-7) → (4-fluoropiperidin-1-yl)(phenyl)methanone

Guidance literature:

With silver nitrate; Selectfluor; trifluoroacetic acid; In dichloromethane; water; at 50 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1021/ja509548z

Reference yield:

phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-yl)methanone (1440956-21-7) → 1-benzoylpiperidin-4-ylboronic acid (1440956-51-3)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 - 80 ℃;

DOI:10.1002/anie.201206681

upstream raw materials:

bis(pinacol)diborane

Downstream raw materials:

1-benzoylpiperidin-4-ylboronic acid

phenyl (4-(trifluoromethyl)piperidin-1-yl)methanone