Technology Process of 5-(4-Chlorophenylsulfonyl)-8-fluoro-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline
There total 8 articles about 5-(4-Chlorophenylsulfonyl)-8-fluoro-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine;
In
ethanol; acetic acid;
at 95 ℃;
for 1h;
- Guidance literature:
-
With
hydrazine hydrate; acetic acid;
In
ethanol;
at 20 ℃;
DOI:10.1021/jm301741t
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C
2.1: pyridine / 5.5 h / 0 - 70 °C
3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C
4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3.25 h / -5 - 20 °C
5.1: aluminum (III) chloride / dichloromethane / -5 - 20 °C
5.2: 7 h
6.1: 3 h / 100 °C
7.1: acetic acid; hydrazine hydrate / ethanol / 20 °C
With
pyridine; aluminum (III) chloride; oxalyl dichloride; sodium tris(acetoxy)borohydride; hydrazine hydrate; acetic acid; trifluoroacetic acid;
In
ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
5.1: |Friedel-Crafts Alkylation / 5.2: |Friedel-Crafts Alkylation;
DOI:10.1021/jm301741t
