1,2,3,4-tetrahydro-4-(4-methylphenyl)-6-phenyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-4-(4-methylphenyl)-6-phenyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester
• CAS No.: 347321-62-4
• Molecular Formula: C₂₀H₂₀N₂O₂S
• Molecular Weight: 352.457
• Mol file: 347321-62-4.mol

Synonyms:1,2,3,4-tetrahydro-4-(4-methylphenyl)-6-phenyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

Chemical Property of 1,2,3,4-tetrahydro-4-(4-methylphenyl)-6-phenyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,4-tetrahydro-4-(4-methylphenyl)-6-phenyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

There total 1 articles about 1,2,3,4-tetrahydro-4-(4-methylphenyl)-6-phenyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methyl-benzaldehyde (104-87-0) + ethyl 3-oxo-3-phenylpropionate (94-02-0) + thiourea (17356-08-0) → 1,2,3,4-tetrahydro-4-(4-methylphenyl)-6-phenyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester (347321-62-4)

Guidance literature:

With cerium(III) p-toluenesulfonate tetrahydrate; In neat (no solvent); at 80 ℃; for 1h; Green chemistry;

DOI:10.1080/00304948.2020.1794222

Reference yield: 84.0%

1,2,3,4-tetrahydro-4-(4-methylphenyl)-6-phenyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester (347321-62-4) + phenol (108-95-2,27073-41-2) → C26H22N2O3

Guidance literature:

With copper diacetate; silver carbonate; In toluene; at 80 ℃;

DOI:10.1039/d1ra07713a

Reference yield: 42.0%

1,2,3,4-tetrahydro-4-(4-methylphenyl)-6-phenyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester (347321-62-4) + 4-methoxy-phenol (150-76-5) → ethyl 2-(4-methoxyphenoxy)-4-phenyl-6-(p-tolyl)pyrimidine-5-carboxylate

Guidance literature:

With potassium phosphate; copper(I) thiophene-2-carboxylate; palladium diacetate; tris-(o-tolyl)phosphine; In toluene; at 100 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.1c00273

upstream raw materials:

4-methyl-benzaldehyde

ethyl 3-oxo-3-phenylpropionate

thiourea