ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylaminobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothienol<2,3-d>pyrimidine-3-acetate

Base Information

• Chemical Name: ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylaminobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothienol<2,3-d>pyrimidine-3-acetate
• CAS No.: 165809-19-8
• Molecular Formula: C₂₆H₂₇N₃O₅S
• Molecular Weight: 493.583

Synonyms:ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylaminobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothienol<2,3-d>pyrimidine-3-acetate

Chemical Property of ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylaminobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothienol<2,3-d>pyrimidine-3-acetate

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Technology Process of ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylaminobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothienol<2,3-d>pyrimidine-3-acetate

There total 2 articles about ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylaminobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothienol<2,3-d>pyrimidine-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

dimethylsulfide-boric acid + ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate (165809-18-7) → ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylaminobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothienol<2,3-d>pyrimidine-3-acetate (165809-19-8)

Guidance literature:

With hydrogenchloride; formic acid; sodium chloride; acetic anhydride; sodium hydrogencarbonate; In tetrahydrofuran; methanol;

Reference yield:

formyl acetic anhydride (2258-42-6) + ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate (165809-18-7) → ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylaminobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothienol<2,3-d>pyrimidine-3-acetate (165809-19-8)

Guidance literature:

With dimethylsulfide borane complex; Multistep reaction; 1.) -20 deg C, 30 min, 2.) RT, 30 min;

DOI:10.1248/cpb.46.1724

Reference yield: 100.0%

ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylaminobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothienol<2,3-d>pyrimidine-3-acetate (165809-19-8) → [6-(4-methoxy-phenyl)-5-methyl-1-(2-methylamino-benzyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; for 1.5h; Ambient temperature;

DOI:10.1248/cpb.46.1724

upstream raw materials:

formyl acetic anhydride

ethyl 2,4(1H,3H)-dioxo-1-(2-aminobenzyl)-5-methyl-6-(4-methoxyphenyl)thieno[2,3-d]pyrimidine-3-acetate

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