1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

Base Information

Chemical Name:1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride
CAS No.:1089209-37-9
Molecular Formula:C₂₅H₂₇ClF₃NO₂*ClH
Molecular Weight:502.404
Hs Code.:

Synonyms:1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

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Chemical Property of 1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

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Technology Process of 1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

There total 5 articles about 1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.7%

: 1089209-36-8
1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane

: 1089209-37-9
1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; isopropyl alcohol;

Reference yield:

: 4790-91-4
5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-ol

: 1089209-37-9
1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 3 h / Heating / reflux

2: sodium methylate / methanol / 30 h / 20 °C / Heating / reflux

3: hydrogenchloride / ethyl acetate; isopropyl alcohol

With hydrogenchloride; sodium methylate; In methanol; ethyl acetate; isopropyl alcohol;

Reference yield:

: 1089210-07-0
5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl acetate

: 1089209-37-9
1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; potassium hydroxide / 0.5 h / 10 - 18 °C

2: sodium methylate / methanol / 3 h / Heating / reflux

3: sodium methylate / methanol / 30 h / 20 °C / Heating / reflux

4: hydrogenchloride / ethyl acetate; isopropyl alcohol

With hydrogenchloride; methanol; potassium hydroxide; sodium methylate; In methanol; ethyl acetate; isopropyl alcohol;