1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane

Base Information

Chemical Name:1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane
CAS No.:1089209-36-8
Molecular Formula:C₂₅H₂₇ClF₃NO₂
Molecular Weight:465.943
Hs Code.:

Synonyms:1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane

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Chemical Property of 1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane

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Technology Process of 1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane

There total 3 articles about 1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.9%

: 65040-68-8
4-(3-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine

: 1089210-19-4
2,3-dihydro-2,2-dimethyl-5-chloro-7-(3-chloro-propoxy)-benzofuran

: 1089209-36-8
1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 30h; Heating / reflux;

Reference yield:

: 1089210-07-0
5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl acetate

: 1089209-36-8
1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; potassium hydroxide / 0.5 h / 10 - 18 °C

2: sodium methylate / methanol / 3 h / Heating / reflux

3: sodium methylate / methanol / 30 h / 20 °C / Heating / reflux

With methanol; potassium hydroxide; sodium methylate; In methanol;

Reference yield:

: 4790-91-4
5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-ol

: 1089209-36-8
1-[(2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / 3 h / Heating / reflux

2: sodium methylate / methanol / 30 h / 20 °C / Heating / reflux

With sodium methylate; In methanol;