N⁶-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-8-(3-{[2-(4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenyl)acetyl]amino}prop-1-yn-1-yl)adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Base Information

• Chemical Name: N⁶-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-8-(3-{[2-(4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenyl)acetyl]amino}prop-1-yn-1-yl)adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• CAS No.: 1017238-59-3
• Molecular Formula: C₇₉H₈₂N₉O₁₂P
• Molecular Weight: 1380.55

Synonyms:N⁶-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-8-(3-{[2-(4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenyl)acetyl]amino}prop-1-yn-1-yl)adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Chemical Property of N⁶-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-8-(3-{[2-(4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenyl)acetyl]amino}prop-1-yn-1-yl)adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

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Technology Process of N⁶-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-8-(3-{[2-(4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenyl)acetyl]amino}prop-1-yn-1-yl)adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

There total 1 articles about N⁶-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-8-(3-{[2-(4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenyl)acetyl]amino}prop-1-yn-1-yl)adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

N6-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-8-(3-{[2-(4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenyl)acetyl]amino}prop-1-yn-1-yl)adenosine (1017238-63-9) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → N6-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-8-(3-{[2-(4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenyl)acetyl]amino}prop-1-yn-1-yl)adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (1017238-59-3)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1002/hlca.200890008

upstream raw materials:

N⁶-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-8-(3-{[2-(4-{3-[6,7-dimethoxy-3-(4-methoxyphenyl)-2-oxoquinolin-1(2H)-yl]propyl}phenyl)acetyl]amino}prop-1-yn-1-yl)adenosine

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

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