2,2,2-trichloroethyl 3-(4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxy-5-nitrophenoxy)propionate

Base Information

Chemical Name:2,2,2-trichloroethyl 3-(4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxy-5-nitrophenoxy)propionate
CAS No.:550356-16-6
Molecular Formula:C₁₈H₂₁Cl₃N₂O₈
Molecular Weight:499.732
Hs Code.:

Synonyms:2,2,2-trichloroethyl 3-(4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxy-5-nitrophenoxy)propionate

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Chemical Property of 2,2,2-trichloroethyl 3-(4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxy-5-nitrophenoxy)propionate

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Technology Process of 2,2,2-trichloroethyl 3-(4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxy-5-nitrophenoxy)propionate

There total 5 articles about 2,2,2-trichloroethyl 3-(4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxy-5-nitrophenoxy)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 5-methoxy-2-nitro-4-[3-oxo-(2,2,2-trichloroethoxy)propoxy]benzoic acid chloride

: 550356-16-6
2,2,2-trichloroethyl 3-(4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxy-5-nitrophenoxy)propionate

Guidance literature:: With potassium carbonate; In acetonitrile; at -40 - 20 ℃; for 0.666667h;
DOI:10.1021/jm020526p

Reference yield:

: 3-(4-formyl-2-methoxy-5-nitrophenoxy)propionic acid chloride

: 550356-16-6
2,2,2-trichloroethyl 3-(4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxy-5-nitrophenoxy)propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 6.94 g / pyridine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 75 percent / aq. H₂O₂; NaClO₂; NaH₂PO₄ / acetonitrile / 1.5 h / 20 °C

3: (COCl)2; DMF / acetonitrile / 16 h / 20 °C

4: 1.10 g / K₂CO₃ / acetonitrile / 0.67 h / -40 - 20 °C

With pyridine; sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; dihydrogen peroxide; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;
DOI:10.1021/jm020526p

Reference yield:

: 550356-12-2
3-(4-formyl-2-methoxy-5-nitrophenoxy)propionic acid

: 550356-16-6
2,2,2-trichloroethyl 3-(4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxy-5-nitrophenoxy)propionate

Guidance literature:: Multi-step reaction with 5 steps

1: (COCl)2; DMF / CH₂Cl₂ / 18 h / 20 °C

2: 6.94 g / pyridine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

3: 75 percent / aq. H₂O₂; NaClO₂; NaH₂PO₄ / acetonitrile / 1.5 h / 20 °C

4: (COCl)2; DMF / acetonitrile / 16 h / 20 °C

5: 1.10 g / K₂CO₃ / acetonitrile / 0.67 h / -40 - 20 °C

With pyridine; sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; dihydrogen peroxide; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;
DOI:10.1021/jm020526p