8-chloro-5-(3-fluorophenyl)-N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide trifluoroacetate

Base Information

Chemical Name:8-chloro-5-(3-fluorophenyl)-N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide trifluoroacetate
CAS No.:1341232-11-8
Molecular Formula:C₂HF₃O₂*C₁₆H₁₃ClFN₃O₂
Molecular Weight:447.773
Hs Code.:

Synonyms:8-chloro-5-(3-fluorophenyl)-N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide trifluoroacetate

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Chemical Property of 8-chloro-5-(3-fluorophenyl)-N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide trifluoroacetate

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Technology Process of 8-chloro-5-(3-fluorophenyl)-N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide trifluoroacetate

There total 9 articles about 8-chloro-5-(3-fluorophenyl)-N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: Ν,Ο-dimethylhydroxylamine hydrochloride

: 1341232-09-4
8-chloro-5-(3-fluorophenyl)imidazo[1,2-a]pyridine-6-carboxylic acid

: 76-05-1
trifluoroacetic acid

: 1341232-11-8
8-chloro-5-(3-fluorophenyl)-N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide trifluoroacetate

Guidance literature:: Ν,Ο-dimethylhydroxylamine hydrochloride; 8-chloro-5-(3-fluorophenyl)imidazo[1,2-a]pyridine-6-carboxylic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; for 2h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 67754-03-4
methyl 2,5-dichloronicotinate

: 1341232-11-8
8-chloro-5-(3-fluorophenyl)-N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 14.5 h / 80 °C / Inert atmosphere

2.1: peracetic acid / 1 h / 90 °C

3.1: trichlorophosphate / 1 h / 90 °C

4.1: ethanol / 0.5 h / Reflux

5.1: trifluoroacetic acid / 22 h / 60 °C

6.1: ethanol; water / 60 °C / Reflux

7.1: sodium hydroxide; water / water; tetrahydrofuran / 6 h / 20 °C

7.2: 0 °C

8.1: N,N-dimethyl-formamide; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 2 h

With peracetic acid; 1-hydroxy-7-aza-benzotriazole; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

: 59782-85-3
2,5-dichloronicotinic acid

: 1341232-11-8
8-chloro-5-(3-fluorophenyl)-N-methoxy-N-methylimidazo[1,2-a]pyridine-6-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 18 h / 20 °C

1.2: 0.5 h / 0 °C

2.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 14.5 h / 80 °C / Inert atmosphere

3.1: peracetic acid / 1 h / 90 °C

4.1: trichlorophosphate / 1 h / 90 °C

5.1: ethanol / 0.5 h / Reflux

6.1: trifluoroacetic acid / 22 h / 60 °C

7.1: ethanol; water / 60 °C / Reflux

8.1: sodium hydroxide; water / water; tetrahydrofuran / 6 h / 20 °C

8.2: 0 °C

9.1: N,N-dimethyl-formamide; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 2 h

With peracetic acid; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;